The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
about
The analysis of clonal expansions in normal and autoimmune B cell repertoiresAntibody responses to envelope glycoproteins in HIV-1 infectionDevelopment of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infectionA Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV ImmunogenProgress in HIV-1 vaccine development.Targeting host-derived glycans on enveloped viruses for antibody-based vaccine designGlycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodiesAccurate and predictive antibody repertoire profiling by molecular amplification fingerprintingConsistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence AnnotationPractical guidelines for B-cell receptor repertoire sequencing analysisAssigning and visualizing germline genes in antibody repertoiresHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Computational tools for epitope vaccine design and evaluationClonify: unseeded antibody lineage assignment from next-generation sequencing dataA human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus.Antiviral Functions of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific IgG Antibodies: Effects of Antiretroviral Therapy and Implications for Therapeutic HIV-1 Vaccine Design.How advances in immunology provide insight into improving vaccine efficacy.The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM RepertoiresRecombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.Structural evolution of glycan recognition by a family of potent HIV antibodies.HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelopePharmacokinetics and immunogenicity of broadly neutralizing HIV monoclonal antibodies in macaques.Characterizing immune repertoires by high throughput sequencing: strategies and applications.Anti-V3/Glycan and Anti-MPER Neutralizing Antibodies, but Not Anti-V2/Glycan Site Antibodies, Are Strongly Associated with Greater Anti-HIV-1 Neutralization Breadth and PotencyA critical question for HIV vaccine development: which antibodies to induce?Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFLDynamics of immunoglobulin sequence diversity in HIV-1 infected individuals.Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity.Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis.HIV Vaccine: Recent Advances, Current Roadblocks, and Future Directions.A Bivalent, Chimeric Rabies Virus Expressing Simian Immunodeficiency Virus Envelope Induces Multifunctional Antibody Responses.HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodiesCXCL13 is a plasma biomarker of germinal center activity.Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.Evidence of perturbed germinal center dynamics, but preserved antibody diversity, in end-stage renal disease.Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding.HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant.
P2860
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P2860
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@ast
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@en
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@nl
type
label
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@ast
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@en
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@nl
prefLabel
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@ast
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@en
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@nl
P2093
P2860
P50
P3181
P1433
P1476
The Effects of Somatic Hypermu ...... ly Neutralizing HIV Antibodies
@en
P2093
Arup K Chakraborty
Bryan Briney
Dennis R Burton
Elizabeth P St John
Francois Vigneault
Galit Alter
Jonathan Laserson
Karen F Saye
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1003754
P50
P577
2013-01-01T00:00:00Z