Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity - Wikidata - wikimedia - TriplyDB

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

http://www.wikidata.org/entity/Q27681451

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The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation Characterization of Novel Ribosome-Associated Endoribonuclease SLFN14 from Rabbit Reticulocytes Pseudokinases: update on their functions and evaluation as new drug targets.Molecular mechanisms of human IRE1 activation through dimerization and ligand binding RNase L targets distinct sites in influenza A virus RNAs.Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily.Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response Structural biology of innate immunity.OASes and STING: adaptive evolution in concert Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.Structural Basis for the Non-catalytic Functions of Protein Kinases.Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6 Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.Rapid RNase L-Driven Arrest of Protein Synthesis in the dsRNA Response without Degradation of Translation Machinery.Nucleotide-binding mechanisms in pseudokinases.Evolutionary adaptation revealed by comparative genome analysis of woolly mammoths and elephants.RNase L activates the NLRP3 inflammasome during viral infections.Mitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production.Functional evolution of the OAS1 viral sensor: Insights from old world primates.Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.Curcumin, a natural antioxidant, acts as a noncompetitive inhibitor of human RNase L in presence of its cofactor 2-5A in vitro.Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing.Characterization of the Molecular Crosstalk within the Essential Grc3/Las1 pre-rRNA Processing Complex.Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.A human cellular noncoding RNA activates the antiviral protein 2'-5'-oligoadenylate synthetase 1

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Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

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2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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Manisha Talukdar

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Monica C Pillon

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P2860

Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L

Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

The unfolded protein response signals through high-order assembly of Ire1

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Innate immune messenger 2-5A tethers human RNase L into active high-order complexes

Principles of protein-protein interactions

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