Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity

Item
http://www.wikidata.org/entity/Q27682448
Fragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA LigaseBiochemical and Structural Characterisation of DNA Ligases from Bacteria and Archaea1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities.DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli.The Search for Herbal Antibiotics: An In-Silico Investigation of Antibacterial Phytochemicals.Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD+-dependent polynucleotide ligases.Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones.Iodine-catalyzed synthesis of dibenzo[b,h][1,6]naphthyridine-11-carboxamides via a domino reaction involving double elimination of hydrogen bromide.Regioselective construction of 1,3-diazaheterocycle fused [1,2-a][1,8]naphthyridine derivatives via cascade reaction of quinolines with heterocyclic ketene aminals: a joint experimental-computational approach.Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases.Enzyme-linked electrochemical DNA ligation assay using magnetic beads.
P2860

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity

Item
http://www.wikidata.org/entity/Q27682448
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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type
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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Structure-guided design, synth ...... o anti-staphylococcal activity
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P356
10.1016/J.BMCL.2012.08.094
P407
P433
P478
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P921