Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors
about
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune.New perspectives on the development of antiobesity drugs.
P2860
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@ast
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@en
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@nl
type
label
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@ast
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@en
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@nl
prefLabel
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@ast
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@en
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@nl
P2093
P3181
P356
P1476
Free-Wilson and structural app ...... e type 1 (11β-HSD1) inhibitors
@en
P2093
Amy C Gyte
Craig S Donald
Cristian Bodin
Frederick W Goldberg
James S Scott
Pablo Morentin Gutierrez
Sam D Groombridge
Stuart N L Bennett
Wendy L Snelson
P304
P3181
P356
10.1021/JM3013163
P407
P50
P577
2012-12-13T00:00:00Z