Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity - Wikidata - wikimedia - TriplyDB

Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity

Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity

http://www.wikidata.org/entity/Q27684054

about

Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead Influenza treatment and prophylaxis with neuraminidase inhibitors: a review Glycotherapy: new advances inspire a reemergence of glycans in medicine Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights The catalytic mechanism of human parainfluenza virus type 3 haemagglutinin-neuraminidase revealed Progress of small molecular inhibitors in the development of anti-influenza virus agents.From neuraminidase inhibitors to conjugates: a step towards better anti-influenza drugs?Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.Emerging antiviral strategies to interfere with influenza virus entry.Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors.A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design.How Viruses Invade Cells.The sweet spot: defining virus-sialic acid interactions.Glycoprofiling as a novel tool in serological assays of systemic sclerosis: a comparative study with three bioanalytical methods.Realizing the Promise of Chemical Glycobiology.A facile microwave-assisted protocol for rapid synthesis of N-acetylneuraminic acid congeners Drugs to cure avian influenza infection--multiple ways to prevent cell death Dissecting conformational contributions to glycosidase catalysis and inhibition.pKa cycling of the general acid/base in glycoside hydrolase families 33 and 34.Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.The chemistry and biology of guanidine natural products.Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties.Can glycoprofiling be helpful in detecting prostate cancer?From covalent glycosidase inhibitors to activity-based glycosidase probes.Bifunctional thiosialosides inhibit influenza virus.The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding.Highly specific and rapid glycan based amperometric detection of influenza viruses.A sialosyl sulfonate as a potent inhibitor of influenza virus replication.Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method.Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration.Synthesis, self-assembly, and immunological activity of α-galactose-functionalized dendron-lipid amphiphiles.Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.Comparison of the 2D and 3D Nanostructured Lectin-Based Biosensors for In Situ Detection of Sialic Acid on Glycoproteins.Electrochemical assay to detect influenza viruses and measure drug susceptibility.Solid phase assay for comparing reactivation rates of neuraminidases of influenza wild type and resistant mutants after inhibitor removal.Understanding viral neuraminidase inhibition by substituted difluorosialic acids.Novel oral anti-influenza drug candidate AV5080.Infectious diseases: Novel agents fight flu infection.

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Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity

http://www.wikidata.org/entity/Q27684054

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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Processing of X-ray diffraction data collected in oscillation mode

The Structure of Clostridium perfringens NanI Sialidase and Its Catalytic Intermediates

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase

Overview of the CCP4 suite and current developments

Linking Crystallographic Model and Data Quality

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

Phasercrystallographic software

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