Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy

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http://www.wikidata.org/entity/Q27684895
Q28393241
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Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosaPossible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disordersThe 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic painPeripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptivePharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors.Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin SubstitutesSoluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases.In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors.Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation.Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury.Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase.Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target.CYP2J2 - regulation, function and polymorphism.Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors
P2860

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy

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http://www.wikidata.org/entity/Q27684895
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@ast
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@en
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
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type
label
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@ast
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@en
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@nl
prefLabel
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@ast
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@en
Optimized inhibitors of solubl ...... ence time and in vivo efficacy
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
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P5875
P698
P921
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P1433
P1476
Optimized Inhibitors of Solubl ...... ence Time and in Vivo Efficacy
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932