Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products
about
Tailoring D-amino acid oxidase from the pig kidney to R-stereoselective amine oxidase and its use in the deracemization of α-methylbenzylamineStructure, Activity and Stereoselectivity of NADPH-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-MethylpyrrolineConcerted amidation of activated esters: reaction path and origins of selectivity in the kinetic resolution of cyclic amines via N-heterocyclic carbenes and hydroxamic acid cocatalyzed acyl transfer.SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution.Chiral amine synthesis using ω-transaminases: an amine donor that displaces equilibria and enables high-throughput screening.New recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates.Monoamine oxidase A and B substrates: probing the pathway for drug development.Artificial concurrent catalytic processes involving enzymes.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Bioinspired therapeutic dendrimers as efficient peptide drugs based on supramolecular interactions for tumor inhibition.Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds.Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic IminesA regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines.Enzymatic and Chemoenzymatic Three-Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines.The role of biocatalysis in the asymmetric synthesis of alkaloids.Continuous-flow oxidative cyanation of primary and secondary amines using singlet oxygen.Directed Evolution of Artificial Imine Reductase.Rational and Semirational Protein Design.Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity.Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines.A biocatalytic cascade for the amination of unfunctionalised cycloalkanes.A New Generation of Smart Amine Donors for Transaminase-Mediated Biotransformations.Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An Acetal Pool Strategy.Immobilised whole-cell recombinant monoamine oxidase biocatalysis.InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines.Biocatalytic oxidation reactions - a Chemist's perspective.NAD(P)H‐Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application.Role of conformational dynamics in the evolution of novel enzyme function.Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-NKinetic Resolution and Deracemization of Racemic Amines Using a Reductive AminaseBiocatalytic Routes to Enantiomerically Enriched Dibenz[c ,e ]azepinesPutrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from PolyaminesBiocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral AminesCatalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesisDeracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variantsDevelopment of an R -Selective Amine Oxidase with Broad Substrate Specificity and High EnantioselectivityMonoamine Oxidase-ω-Transaminase Cascade for the Deracemisation and Dealkylation of AminesAsymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine ReductaseExpansion of the Substrate Specificity of Porcine Kidney D-Amino Acid Oxidase for -Stereoselective Oxidation of 4-Cl-Benzhydrylamine
P2860
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P2860
Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products
description
2013 nî lūn-bûn
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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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name
Engineering an enantioselectiv ...... and alkaloid natural products
@ast
Engineering an enantioselectiv ...... and alkaloid natural products
@en
Engineering an enantioselectiv ...... and alkaloid natural products
@nl
type
label
Engineering an enantioselectiv ...... and alkaloid natural products
@ast
Engineering an enantioselectiv ...... and alkaloid natural products
@en
Engineering an enantioselectiv ...... and alkaloid natural products
@nl
prefLabel
Engineering an enantioselectiv ...... and alkaloid natural products
@ast
Engineering an enantioselectiv ...... and alkaloid natural products
@en
Engineering an enantioselectiv ...... and alkaloid natural products
@nl
P2093
P3181
P356
P1476
Engineering an enantioselectiv ...... and alkaloid natural products
@en
P2093
Annika Frank
Diego Ghislieri
Gideon Grogan
Ian Rowles
Marta Pontini
Simon C Willies
P304
P3181
P356
10.1021/JA4051235
P407
P577
2013-07-24T00:00:00Z