An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
about
Human IgG4: a structural perspectivePrinciples of antibody-mediated TNF receptor activationStructural Determinants of Unique Properties of Human IgG4-FcDynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Agonist, GLP-1-IgG2σ-Fc.Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cellsAnti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies.Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions.Deglycosylation of mAb by EndoS for improved molecular imaging.Strategies and challenges for the next generation of antibody-drug conjugates.Current progress in innovative engineered antibodies.Enhancement of antibody functions through Fc multiplications.Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI.Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.The making of bispecific antibodiesIncreased in vivo effector function of human IgG4 isotype antibodies through afucosylation.Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer TherapyRapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding.IgG Fc engineering to modulate antibody effector functions.FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody.Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties.Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactionsHuman antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
P2860
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P2860
An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
description
2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2014 թվականի հունվարին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
An engineered Fc variant of an ...... s via structural perturbations
@ast
An engineered Fc variant of an ...... s via structural perturbations
@en
An engineered Fc variant of an ...... s via structural perturbations
@nl
type
label
An engineered Fc variant of an ...... s via structural perturbations
@ast
An engineered Fc variant of an ...... s via structural perturbations
@en
An engineered Fc variant of an ...... s via structural perturbations
@nl
prefLabel
An engineered Fc variant of an ...... s via structural perturbations
@ast
An engineered Fc variant of an ...... s via structural perturbations
@en
An engineered Fc variant of an ...... s via structural perturbations
@nl
P2093
P3181
P1433
P1476
An engineered Fc variant of an ...... s via structural perturbations
@en
P2093
Bernard Scallon
Brandy Strake
Eilyn R Lacy
Gary L Gilliland
Teresa Wilkinson
Thomas J Malia
William R Strohl
P304
P3181
P356
10.1016/J.YMETH.2013.06.035
P577
2013-07-17T00:00:00Z