Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

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http://www.wikidata.org/entity/Q27688061
PI3K isoform-selective inhibitors: next-generation targeted cancer therapiesRecent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agentsNanomicellar TGX221 blocks xenograft tumor growth of prostate cancer in nude mice.Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophilaThe use of small-molecule structures to complement protein-ligand crystal structures in drug discoveryPI-3 kinase p110β: a therapeutic target in advanced prostate cancers.Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells.P110β Inhibition Reduces Histone H3K4 Di-Methylation in Prostate Cancer.Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors.Overcoming resistance to BRAF inhibitors.First-in-human trial of the PI3Kβ-selective inhibitor SAR260301 in patients with advanced solid tumors.Non-Debye frustrated hydration steers biomolecular association: interfacial tension for the drug designer.
P2860

Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

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http://www.wikidata.org/entity/Q27688061
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Discovery and optimization of ...... logue (PTEN)-deficient cancers
@ast
Discovery and optimization of ...... logue (PTEN)-deficient cancers
@en
Discovery and optimization of ...... logue (PTEN)-deficient cancers
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type
label
Discovery and optimization of ...... logue (PTEN)-deficient cancers
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Discovery and optimization of ...... logue (PTEN)-deficient cancers
@en
Discovery and optimization of ...... logue (PTEN)-deficient cancers
@nl
prefLabel
Discovery and optimization of ...... logue (PTEN)-deficient cancers
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Discovery and optimization of ...... logue (PTEN)-deficient cancers
@en
Discovery and optimization of ...... logue (PTEN)-deficient cancers
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Discovery and optimization of ...... logue (PTEN)-deficient cancers
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P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698