First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway - Wikidata - wikimedia - TriplyDB

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

http://www.wikidata.org/entity/Q27698508

about

Personalized Clinical Trials in Hepatocellular Carcinoma Based on Biomarker Selection Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances Targeting cancer with kinase inhibitors Pseudokinases: update on their functions and evaluation as new drug targets.Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.Determining Cysteines Available for Covalent Inhibition Across the Human Kinome.Multiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).FGFR Family Members Protein Expression as Prognostic Markers in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo A miR-7/GAS6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma.Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.Design, Synthesis and Anti-Proliferative Activities of 2,6-Substituted Thieno[3,2-d]pyrimidine Derivatives Containing Electrophilic Warheads.Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing.Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging FGFR3 promotes angiogenesis-dependent metastasis of hepatocellular carcinoma via facilitating MCP-1-mediated vascular formation.The role of phosphate in kidney disease.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.Mutation Detection of Fibroblast Growth Factor Receptor 3 for Infiltrative Hepatocellular Carcinoma by Whole-Exome Sequencing.Advances and challenges in targeting FGFR signalling in cancer.Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity.FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib.Emerging roles of FGF signaling in hepatocellular carcinoma.Clinicopathological examination of dipeptidase 1 expression in colorectal cancer.Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma.Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice.2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors.Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi-slice spiral CT and MRI.The integration of genomics testing and functional proteomics in the era of personalized medicine.Implications of FGF19 on sorafenib-mediated nitric oxide production in hepatocellular carcinoma cells - a short report.Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth.RAS-MAPK reactivation facilitates acquired resistance in FGFR1-amplified lung cancer and underlies a rationale for upfront FGFR-MEK blockade.Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?FGFR4 Arg388 Is Correlated with Poor Survival in Resected Colon Cancer Promoting Epithelial to Mesenchymal Transition.Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.Systematic identification of cancer-specific MHC-binding peptides with RAVEN Molecular heterogeneity in hepatocellular carcinoma Hepatocellular carcinoma

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P2860

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

http://www.wikidata.org/entity/Q27698508

description

2015 nî lūn-bûn

@nan

2015 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

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2015年论文

@wuu

name

First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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2159-8290.CD-14-1029

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Cancer Discovery

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First Selective Small Molecule ...... ivated FGFR4 Signaling Pathway

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Adam Shutes

http://www.w3.org/2001/XMLSchema#string

Brian Hodous

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Chandra Miduturu

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Christopher Winter

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Joseph L Kim

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Margit Hagel

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Michael Sheets

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Nancy E Kohl

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Natasja Brooijmans

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Neil Bifulco

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424-37

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scholarly article

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930602

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10.1158/2159-8290.CD-14-1029

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Christoph Lengauer

Nicolas Stransky

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2015-04-01T00:00:00Z

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25776529

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