Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
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Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturitionCellular and molecular regulation of innate inflammatory responsesMolecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis.Nur77 deficiency leads to systemic inflammation in elderly mice.Simultaneous targeting of MyD88 and Nur77 as an effective approach for the treatment of inflammatory diseasesNur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression.Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulationTranscription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.Nurr1-Based Therapies for Parkinson's Disease.Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1.Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model.Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation.A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy.Emerging roles of orphan nuclear receptors in regulation of innate immunity.The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases.Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death.NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis.Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance.Orphan nuclear receptor Nur77 inhibits poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20.Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice.Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function.Regulation of cAMP Responsive Element Binding Protein 3-Like 1 (Creb3l1) Expression by Orphan Nuclear Receptor Nr4a1.The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial MetabolismThe E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2αCompensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in AstrocytesNuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
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Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
description
2015 nî lūn-bûn
@nan
2015 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@ast
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@en
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@nl
type
label
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@ast
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@en
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@nl
prefLabel
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@ast
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@en
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@nl
P2093
P2860
P921
P3181
P356
P1476
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
@en
P2093
An-zhong Li
Feng-wei Li
Hang-zi Chen
Hong-kui Zhang
Jiahuai Han
Jian-feng Wu
Jian-ping He
Qian Zhang
P2860
P2888
P304
P3181
P356
10.1038/NCHEMBIO.1788
P577
2015-03-30T00:00:00Z
P5875
P6179
1044149448