The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propana

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propana

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http://www.wikidata.org/entity/Q27703515
Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agentsAnalysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine TumorsConformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1).The role of PI3Kα isoform in cardioprotection.New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound.Tandem Aryne-Capture/Sigmatropic Rearrangement as a Metal-Free Entry to Functionalized N-Aryl Pyrrolidines.Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.Gelidiella acerosa inhibits lung cancer proliferation.Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
P2860

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propana

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http://www.wikidata.org/entity/Q27703515
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
The Rational Design of Selecti ...... [1,4]oxazepin-9-yl)oxy)propana
@nl
type
label
The Rational Design of Selecti ...... [1,4]oxazepin-9-yl)oxy)propana
@nl
prefLabel
The Rational Design of Selecti ...... [1,4]oxazepin-9-yl)oxy)propana
@nl
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P1476
P2093
P304
P31
P356
P407
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P478
P50
P577
P698
P356
P1433
P1476
The Rational Design of Selecti ...... -yl)oxy)propanamide (GDC-0326)
@en
P2093
P304
P31
P356
10.1021/ACS.JMEDCHEM.5B01483
P407
P433
P478
P50
P577
P698