The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
about
The nuts and bolts of the endogenous spliceosomeStructure of a yeast activated spliceosome at 3.5 Å resolutionStructure of a yeast catalytic step I spliceosome at 3.4 Å resolutionCryo-EM structure of the spliceosome immediately after branchingMolecular architecture of the Saccharomyces cerevisiae activated spliceosomeStructural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density mapsResolution advances in cryo-EM enable application to drug discovery.Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.STRUCTURE. A Big Bang in spliceosome structural biology.Biological cryo-electron microscopy in ChinaStructural studies of the endogenous spliceosome - The supraspliceosome.Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivitySubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.Splice-switching antisense oligonucleotides as therapeutic drugsWhat have single-molecule studies taught us about gene expression?Unravelling biological macromolecules with cryo-electron microscopy.Two novel mutations in PRPF3 causing autosomal dominant retinitis pigmentosa.A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex.Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.Methodologies for studying the spliceosome's RNA dynamics with single-molecule FRET.Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.Lights, camera, action! Capturing the spliceosome and pre-mRNA splicing with single-molecule fluorescence microscopy.Therapeutic targeting of splicing in cancer.While the revolution will not be crystallized, biochemistry reigns supreme.Functions and regulation of the Brr2 RNA helicase during splicing.Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise.Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.Genetics and biochemistry remain essential in the structural era of the spliceosome.Structural Insights into the Mechanism of Group II Intron Splicing.Structural biology: Catalytic spliceosome captured.Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activitiesA new role for FBP21 as regulator of Brr2 helicase activity.Structure of a pre-catalytic spliceosome.A close-up look at the spliceosome, at last.A protein map of the yeast activated spliceosome as obtained by electron microscopyBasal-A Triple Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival.Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.Globular domain structure and function of restriction-like-endonuclease LINEs: similarities to eukaryotic splicing factor Prp8.Nucleic acids: function and potential for abiogenesis.
P2860
Q26741296-DE154CA7-5DEB-44E5-9126-8C5DA771917DQ27721209-EB18AA76-8C36-4B66-B213-AC166318EBD1Q27721261-6268F0C3-D30A-458C-B008-D683DA04BEE6Q27722247-B7ADB3F4-C56E-4D57-8637-854E3EF3AA3DQ27727737-C4CF579D-2AE1-4A53-9D70-6D3495E238C0Q28315106-DD1C5D1E-6DC0-4C3B-84C9-04E60E9E99C4Q30276077-ECB5BD37-82D2-4B0B-A649-6A1465E2095AQ30360791-71B7C857-34C7-4BD0-9424-F4BC198558B3Q34519777-ACB722EB-CEE1-4D39-9423-852EBA144865Q36106092-E0FA63C1-B91C-400E-BD1F-ED72A28C854DQ36347782-E61C0856-977E-4AD2-B2E7-3702C452DB7DQ37065956-6CD9DF2A-A040-4AE1-A5C1-69439CD96DF8Q37102340-67AC4E1E-0A86-48D4-B410-E293406B6DC4Q37179880-50382CF5-A861-48E7-AD6B-7548CF9CAC66Q37211004-2739B022-2208-4435-AD0E-65E3EF5AA3AEQ37258757-277F49C6-147A-4CF0-A213-12BE7C6D15D6Q37357527-E70246FA-D585-47E5-A28B-282D4DA465DAQ37439383-8FA3733B-62CB-4717-BFB3-B000E5039DC4Q37507536-8F3B013E-6A05-4957-A6FB-A6DA3DFB1202Q38597161-18394205-3DC4-4878-82FF-71FB762EE006Q38772354-70C37438-AD20-4929-AC07-13B357535820Q38833557-E82F42D9-8C37-47F0-8B65-DE2E03273127Q38838948-7A341822-8FE8-43F3-92CC-2D94303EB250Q38948363-4F90B8AC-CB3D-409E-A531-A5184E5B431AQ38965623-328C4A72-F1EF-4BE7-BB28-1119D184D3A9Q38993788-35F983C4-CA8D-4097-A45D-EDB29E7AF69CQ39010502-747BBEA8-673A-4341-87F0-F662B5D1DAD3Q39043264-D16689EA-701B-44BE-B034-D3F980CEA3CFQ39108397-CDF76E42-7096-45D5-A1CF-A966A1D3FCAAQ39259302-6C393092-D767-4823-8B72-AEB9DB438A27Q39503527-1986E774-994A-44BA-9AE5-E3548A74FAC9Q41477455-53CA886F-12F3-4EC2-86E8-FCF1E8CB9767Q41510811-29AB076C-B58B-4820-A8D4-5FF7D215A880Q41597888-F3DE27CA-1829-4669-ABAB-44B63F407D00Q41598279-03E4074D-1D70-43AA-88B0-A0FA15C43608Q41746776-30B91915-45B7-4F05-8BA5-3EB52174E3F4Q42514519-ABF3DF0E-2CED-4488-91E3-CC743F190AFEQ45765008-A43CE5F8-D820-4900-AED7-308DFB9D8D79Q46170660-D0915A20-874A-4460-84F5-A10F574A6DB7Q46242768-43593161-8A67-4800-8FB1-71157724F37C
P2860
The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
description
2016 nî lūn-bûn
@nan
2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@ast
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@en
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@nl
type
label
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@ast
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@en
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@nl
prefLabel
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@ast
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@en
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@nl
P2093
P2860
P3181
P356
P1433
P1476
The 3.8 Å structure of the U4/ ...... ceosome assembly and catalysis
@en
P2093
Catherine C L Wong
Chuangye Yan
Ruixue Wan
P2860
P304
P3181
P356
10.1126/SCIENCE.AAD6466
P407
P50
P577
2016-01-29T00:00:00Z