The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design
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Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome.Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.Blockade of the malignant phenotype by β-subunit selective noncovalent inhibition of immuno- and constitutive proteasomes.The structural modification of natural products for novel drug discovery.Activity-based probes for the multicatalytic proteasome.Safety of ixazomib for the treatment of multiple myeloma.Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.High-Resolution Snapshots of Proteasome Inhibitors in Action Revise Inhibition Paradigms and Inspire Next-Generation Inhibitor Design.Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.The versatility of boron in biological target engagement.Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren's syndrome.Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistanceIslet stress, degradation and autoimmunity
P2860
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P2860
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design
description
2016 nî lūn-bûn
@nan
2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
The inhibition mechanism of hu ...... xt-generation inhibitor design
@ast
The inhibition mechanism of hu ...... xt-generation inhibitor design
@en
The inhibition mechanism of hu ...... xt-generation inhibitor design
@nl
type
label
The inhibition mechanism of hu ...... xt-generation inhibitor design
@ast
The inhibition mechanism of hu ...... xt-generation inhibitor design
@en
The inhibition mechanism of hu ...... xt-generation inhibitor design
@nl
prefLabel
The inhibition mechanism of hu ...... xt-generation inhibitor design
@ast
The inhibition mechanism of hu ...... xt-generation inhibitor design
@en
The inhibition mechanism of hu ...... xt-generation inhibitor design
@nl
P2093
P2860
P50
P356
P1433
P1476
The inhibition mechanism of hu ...... xt-generation inhibitor design
@en
P2093
Ashwin Chari
Holger Stark
Jil Schrader
Kai Tittmann
Ricardo A Mata
P2860
P304
P356
10.1126/SCIENCE.AAF8993
P407
P577
2016-08-01T00:00:00Z