Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
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Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2.A novel mutation in the switch 3 region of Gsalpha in a patient with Albright hereditary osteodystrophy impairs GDP binding and receptor activationConditional activation defect of a human Gsalpha mutantDistinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brainAnalysis of the N-terminal binding domain of Go alphaInteraction sites of the C-terminal region of the cGMP phosphodiesterase inhibitory subunit with the GDP-bound transducin alpha-subunitMEK kinases are regulated by EGF and selectively interact with Rac/Cdc42The structural basis of arrestin-mediated regulation of G-protein-coupled receptorsSwitches, latches, and amplifiers: common themes of G proteins and molecular motorsSignal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signalingComputational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network ModelStructure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complexAn open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanismHelix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in Gα i Subunits † , ‡Structural basis for the specific inhibition of heterotrimeric Gq protein by a small moleculeA Constitutively Active Gα Subunit Provides Insights into the Mechanism of G Protein ActivationA transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.A Conserved Phenylalanine as a Relay between the 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein SubunitLight-activated rhodopsin induces structural binding motif in G protein alpha subunitCrystal structure of human RhoA in a dominantly active form complexed with a GTP analogueGPCR-induced dissociation of G-protein subunits in early stage signal transduction.Cell-Autonomous Gβ Signaling Defines Neuron-Specific Steady State Serotonin Synthesis in Caenorhabditis elegansEmbryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.G protein signaling: insights from new structures.Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.Receptor-independent activation of atrial muscarinic potassium channels in the absence of nucleotides.Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.An intact helical domain is required for Gα14 to stimulate phospholipase CβStabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3.Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchangeGuanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.A G-protein beta subunit required for sexual and vegetative development and maintenance of normal G alpha protein levels in Neurospora crassa.Implications of non-canonical G-protein signaling for the immune systemActive site comparisons highlight structural similarities between myosin and other P-loop proteins.Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing.Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1.Motion of carboxyl terminus of Galpha is restricted upon G protein activation. A solution NMR study using semisynthetic Galpha subunits.
P2860
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P2860
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@ast
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@en
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@nl
type
label
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@ast
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@en
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@nl
prefLabel
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@ast
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@en
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@nl
P2093
P3181
P1433
P1476
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.270.5238.954
P407
P577
1995-11-10T00:00:00Z