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A relationship between protein stability and protein function

A relationship between protein stability and protein function

http://www.wikidata.org/entity/Q27730341

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Protein stability promotes evolvability Lessons from the lysozyme of phage T4 Three decades of beta-lactamase inhibitors The pi-helix translates structure into function Improvement in protein functional site prediction by distinguishing structural and functional constraints on protein family evolution using computational design.Consensus protein design Why reinvent the wheel? Building new proteins based on ready-made parts Molecular mechanisms of disease-causing missense mutations Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site Role of non-glycine residues in left-handed helical conformation for the conformational stability of human lysozyme Preorganization of molecular binding sites in designed diiron proteins Zinc Coordination Geometry and Ligand Binding Affinity: The Structural and Kinetic Analysis of the Second-Shell Serine 228 Residue and the Methionine 180 Residue of the Aminopeptidase from Vibrio proteolyticus †Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders Structural Bases for Stability–Function Tradeoffs in Antibiotic Resistance Design of a switchable eliminase Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol Engineering a model protein cavity to catalyze the Kemp elimination The Impact of Introducing a Histidine into an Apolar Cavity Site on Docking and Ligand Recognition A glutamate switch controls voltage-sensitive phosphatase function Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine Detoxification Structural insights into N-terminal to C-terminal interactions and implications for thermostability of a (β/α)8-triosephosphate isomerase barrel enzyme Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β-Lactamases by Relieving Steric Strain Genotype-Phenotype Correlations in Ornithine Transcarbamylase Deficiency: A Mutation Update Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds A highly stable plastidic-type ferredoxin-NADP(H) reductase in the pathogenic bacterium Leptospira interrogans Correlated electrostatic mutations provide a reservoir of stability in HIV protease Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability Contingency and entrenchment in protein evolution under purifying selection The regulation of N-methyl-D-aspartate receptors by Src kinase.Thermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designed Thermostability improvement of a streptomyces xylanase by introducing proline and glutamic acid residues.Computational protein design: validation and possible relevance as a tool for homology searching and fold recognition Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity Effects of Non-Natural Amino Acid Incorporation into the Enzyme Core Region on Enzyme Structure and Function.Substitution, insertion, deletion, suppression, and altered substrate specificity in functional protocatechuate 3,4-dioxygenases.Empirical relationships between protein structure and carboxyl pKa values in proteins.Recent advances in our understanding of protein conformational stability from a pharmaceutical perspective.The (in)dependence of alternative splicing and gene duplication The construction of an amino acid network for understanding protein structure and function.Modulating the thermostability of Endoglucanase I from Trichoderma reesei using computational approaches.

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P2860

A relationship between protein stability and protein function

http://www.wikidata.org/entity/Q27730341

description

1995 nî lūn-bûn

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1995 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1995 թվականի հունվարին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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A relationship between protein stability and protein function

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Proceedings of the National Academy of Sciences of the United States of America

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A relationship between protein stability and protein function

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P2093

B K Shoichet

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B W Matthews

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R Kuroki

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W A Baase

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P2860

Improved methods for building protein models in electron density maps and the location of errors in these models

Multiple alanine replacements within α-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability

A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene

A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme

Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences

Rapid and efficient site-specific mutagenesis without phenotypic selection

Some factors in the interpretation of protein denaturation

Effect of single amino acid substitutions at positions 49 and 60 on the thermal unfolding of the tryptophan synthase alpha subunit from Salmonella typhimurium.

Structure-stability relationship in proteins: fundamental tasks and strategy for the development of stabilized enzyme catalysts for biotechnology.

Deletion of the omega-loop in the active site of staphylococcal nuclease. 1. Effect on catalysis and stability.

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10.1073/PNAS.92.2.452

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2

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92

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42758

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