Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications
about
Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds: alteration of pyridine nucleotide binding by a single amino acid substitutionStructure in an extreme environment: NMR at high saltNMR Structures of Apo L. casei Dihydrofolate Reductase and Its Complexes with Trimethoprim and NADPH: Contributions to Positive Cooperative Binding from Ligand-Induced Refolding, Conformational Changes, and Interligand Hydrophobic InteractionsKeep on moving: discovering and perturbing the conformational dynamics of enzymesToward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+.Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands.Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli).Role of water in the catalytic cycle of E. coli dihydrofolate reductase.Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase.In pursuit of virtual lead optimization: the role of the receptor structure and ensembles in accurate docking.Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.In pursuit of virtual lead optimization: pruning ensembles of receptor structures for increased efficiency and accuracy during docking.Envisioning the loop movements and rotation of the two subdomains of dihydrofolate reductase by elastic normal mode analysis.Electrostatic contributions to protein stability and folding energy.Evolutional design of a hyperactive cysteine- and methionine-free mutant of Escherichia coli dihydrofolate reductase.Slow Dynamics of Tryptophan-Water Networks in Proteins.The role of the Met20 loop in the hydride transfer in Escherichia coli dihydrofolate reductase.
P2860
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P2860
Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications
description
1995 nî lūn-bûn
@nan
1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Isomorphous crystal structures ...... late: mechanistic implications
@ast
Isomorphous crystal structures ...... late: mechanistic implications
@en
Isomorphous crystal structures ...... late: mechanistic implications
@nl
type
label
Isomorphous crystal structures ...... late: mechanistic implications
@ast
Isomorphous crystal structures ...... late: mechanistic implications
@en
Isomorphous crystal structures ...... late: mechanistic implications
@nl
prefLabel
Isomorphous crystal structures ...... late: mechanistic implications
@ast
Isomorphous crystal structures ...... late: mechanistic implications
@en
Isomorphous crystal structures ...... late: mechanistic implications
@nl
P2093
P356
P1433
P1476
Isomorphous crystal structures ...... late: mechanistic implications
@en
P2093
P304
P356
10.1021/BI00008A039
P407
P577
1995-02-28T00:00:00Z