Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus - Wikidata - wikimedia - TriplyDB

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus

http://www.wikidata.org/entity/Q27732077

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INS-gene mutations: from genetics and beta cell biology to clinical disease The solution structure of a superpotent b-chain-shortened single-replacement insulin analogue Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS Protective hinge in insulin opens to enable its receptor engagement The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport Inactive conformation of an insulin despite its wild-type sequence.

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P2860

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus

http://www.wikidata.org/entity/Q27732077

description

1993 nî lūn-bûn

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1993 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1993 թվականի հունվարին հրատարակված գիտական հոդված

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1993年の論文

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年论文

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name

Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Paradoxical structure and func ...... ociated with diabetes mellitus

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Proceedings of the National Academy of Sciences of the United States of America

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Paradoxical structure and func ...... ociated with diabetes mellitus

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P2093

K Inouye

http://www.w3.org/2001/XMLSchema#string

M A Weiss

http://www.w3.org/2001/XMLSchema#string

Q X Hua

http://www.w3.org/2001/XMLSchema#string

S E Shoelson

http://www.w3.org/2001/XMLSchema#string

P2860

A structurally abnormal insulin causing human diabetes

Receptor binding redefined by a structural switch in a mutant human insulin

The structure of 2Zn pig insulin crystals at 1.5 A resolution

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions.

An evaluation of computational strategies for use in the determination of protein structure from distance constraints obtained by nuclear magnetic resonance.

Proton nuclear magnetic resonance study of the B9(Asp) mutant of human insulin. Sequential assignment and secondary structure.

Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin.

Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution

Evidence concerning insulin activity from the structure of a cross-linked derivative.

Single chain des-(B30) insulin. Intramolecular crosslinking of insulin by trypsin catalyzed transpeptidation.

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582-6

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scholarly article

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10.1073/PNAS.90.2.582

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2

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90

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8421693

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