Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine
about
Charting a Path to Success in Virtual ScreeningStructure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallographyA potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitorNP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces speciesThermodynamic linkage between the binding of protons and inhibitors to HIV-1 protease.Molecular docking screens using comparative models of proteinsGenotypic testing for human immunodeficiency virus type 1 drug resistance.Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesisMechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediateJE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand bindingAntimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.A Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies.Modeling Protein-Ligand Binding by Mining Minima.Linkers in the structural biology of protein-protein interactionsWater at biomolecular binding interfaces.Ions and inhibitors in the binding site of HIV protease: comparison of Monte Carlo simulations and the linearized Poisson-Boltzmann theoryModeling molecular recognition: theory and application.Revisiting ligand-induced conformational changes in proteins: essence, advancements, implications and future challenges.Accounting for ligand conformational restriction in calculations of protein-ligand binding affinities.Insights into saquinavir resistance in the G48V HIV-1 protease: quantum calculations and molecular dynamic simulations.Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere.Molecular mechanisms of resistance: free energy calculations of mutation effects on inhibitor binding to HIV-1 protease.Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272.A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking.Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites.Enhanced docking with the mining minima optimizer: acceleration and side-chain flexibility.Accelerated Poisson-Boltzmann calculations for static and dynamic systems.AutoDock-GIST: Incorporating Thermodynamics of Active-Site Water into Scoring Function for Accurate Protein-Ligand Docking.Placevent: an algorithm for prediction of explicit solvent atom distribution-application to HIV-1 protease and F-ATP synthase.
P2860
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P2860
Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@ast
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@en
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@nl
type
label
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@ast
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@en
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@nl
prefLabel
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@ast
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@en
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@nl
P2093
P1433
P1476
Structure of HIV-1 protease wi ...... ontaining allophenylnorstatine
@en
P2093
E T Baldwin
J W Erickson
P304
P356
10.1016/S0969-2126(01)00192-7
P577
1995-06-15T00:00:00Z