Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex
about
Structural basis for the impaired channeling and allosteric inter-subunit communication in the beta A169L/beta C170W mutant of tryptophan synthaseCrystal structure of the beta Ser178--> Pro mutant of tryptophan synthase. A "knock-out" allosteric enzymeLarge conformational changes in the Escherichia coli tryptophan synthase beta(2) subunit upon pyridoxal 5'-phosphate bindingAllostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary StatesElucidating factors important for monovalent cation selectivity in enzymes: E. coli β-galactosidase as a modelCryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49Overexpression and characterization of the human mitochondrial and cytosolic branched-chain aminotransferasesThermal repair of tryptophan synthase mutations in a regulatory intersubunit salt bridge. Evidence from arrhenius plots, absorption spectra, and primary kinetic isotope effects.H2rs: deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments.Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase.Redesigning the monovalent cation specificity of an enzymeDeveloping an energy landscape for the novel function of a (beta/alpha)8 barrel: ammonia conduction through HisF.A structural perspective on enzymes activated by monovalent cations.Role of Na+ and K+ in enzyme function.Gates of enzymes.Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex.Molecular Mechanisms of Enzyme Activation by Monovalent Cations.Tryptophan synthase: structure and function of the monovalent cation site.pH dependence of tryptophan synthase catalytic mechanism: I. The first stage, the beta-elimination reaction.Importance of conserved and variable C-terminal residues for the activity and thermal stability of the beta subunit of tryptophan synthase.Stabilisation of halophilic malate dehydrogenase from Haloarcula marismortui by divalent cations -- effects of temperature, water isotope, cofactor and pH.Allosteric communication of tryptophan synthase. Functional and regulatory properties of the beta S178P mutant.Detection of open and closed conformations of tryptophan synthase by 15N-heteronuclear single-quantum coherence nuclear magnetic resonance of bound 1-15N-L-tryptophan.Molecular dissection of Na+ binding to thrombin.Mutational scanning of a hairpin loop in the tryptophan synthase beta-subunit implicated in allostery and substrate channeling.Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands.Effect of pH and Monovalent Cations on the Formation of Quinonoid Intermediates of the Tryptophan Synthase α2β2Complex in Solution and in the CrystalRoles of hydrogen bonding residues in the interaction between the alpha and beta subunits in the tryptophan synthase complex. Asn-104 of the alpha subunit is especially important.Plasticity of the Tryptophan Synthase Active Site Probed by31P NMR Spectroscopy
P2860
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P2860
Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@ast
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@en
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@nl
type
label
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@ast
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@en
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@nl
prefLabel
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@ast
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@en
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@nl
P2093
P356
P1433
P1476
Exchange of K+ or Cs+ for Na+ ...... n synthase alpha2beta2 complex
@en
P2093
P304
P356
10.1021/BI952506D
P407
P577
1996-04-02T00:00:00Z