Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
about
Specific Inhibition of Bovine Viral Diarrhea Virus ReplicasePotent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease †Molecular recognition of cyclic urea HIV-1 protease inhibitorsHuman immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogsNovel compounds in preclinical/early clinical development for the treatment of HIV infections.Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitorsEffectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.New anti-HIV agents and targets.Inclusion of multiple fragment types in the site identification by ligand competitive saturation (SILCS) approachModeling Protein-Ligand Binding by Mining Minima.Discovery of HIV Type 1 Aspartic Protease Hit Compounds through Combined Computational Approaches.Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site.Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.Water at biomolecular binding interfaces.Accounting for water molecules in drug design.Second generation HIV protease inhibitors against resistant virus.Protease inhibitors as antiviral agents.A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking.Resistance profiles of cyclic and linear inhibitors of HIV-1 protease.Strategies in the Design of Antiviral DrugsPreparation and Structure of Novel Chiral 4,6-Disubstituted Tetrahydropyrimidinones
P2860
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P2860
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@ast
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@en
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@nl
type
label
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@ast
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@en
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@nl
prefLabel
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@ast
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@en
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@nl
P2093
P1476
Improved cyclic urea inhibitor ...... y crystal structure of DMP 450
@en
P2093
C J Eyermann
D A Jackson
D L Winslow
L T Bacheler
P304
P356
10.1016/S1074-5521(96)90110-6
P577
1996-04-01T00:00:00Z