The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding
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Development of a highly-potent anti-angiogenic VEGF8-109 heterodimer by directed blocking of its VEGFR-2 binding siteThe cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factorThe crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolutionStructural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1D2: RECOGNITION AND SPECIFICITYStructure of a mutant β toxin fromStaphylococcus aureusreveals domain swapping and conformational flexibilityTotal Chemical Synthesis of Biologically Active Vascular Endothelial Growth FactorAssignment of the four disulfides in the N-terminal somatomedin B domain of native vitronectin isolated from human plasmaN-linked oligosaccharides play a role in disulphide-dependent dimerization of intestinal mucin Muc2A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft modelsDimerization of VEGF receptors and implications for signal transduction: a computational study.Single-chain vascular endothelial growth factor variant with antagonist activity.Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis.A vascular endothelial growth factor high affinity receptor 1-specific peptide with antiangiogenic activity identified using a phage display peptide library.Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide.Functional contributions of noncysteine residues within the cystine knots of human chorionic gonadotropin subunits.Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.The vascular endothelial growth factor family: signalling for vascular development.The discovery of placenta growth factor and its biological activity.Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site.Aptamer selection based on G4-forming promoter region.Engineered conformation-dependent VEGF peptide mimics are effective in inhibiting VEGF signaling pathways.Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1Expression and role of VEGF in the adult retinal pigment epitheliumCombined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines.Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responsesPeptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy'In-Format' screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules.Placental Growth Factor as a Predictor of Cardiovascular Events in Patients with CKD from the NARA-CKD Study.The role of VEGF receptors in angiogenesis; complex partnershipsNovel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept.VEGFR-2 conformational switch in response to ligand binding.Native MS and ECD Characterization of a Fab-Antigen Complex May Facilitate Crystallization for X-ray DiffractionVEGF-A splicing: the key to anti-angiogenic therapeutics?Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity.Novel vascular endothelial growth factor D variants with increased biological activityDevelopment of a multiplex sandwich aptamer microarray for the detection of VEGF165 and thrombin.Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation.Occurrence, biochemical profile of vascular endothelial growth factor (VEGF) isoforms and their functions in endochondral ossification.Function of members of the neuropilin family as essential pleiotropic cell surface receptors.
P2860
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P2860
The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
The crystal structure of vascu ...... exibility and receptor binding
@ast
The crystal structure of vascu ...... exibility and receptor binding
@en
The crystal structure of vascu ...... exibility and receptor binding
@nl
type
label
The crystal structure of vascu ...... exibility and receptor binding
@ast
The crystal structure of vascu ...... exibility and receptor binding
@en
The crystal structure of vascu ...... exibility and receptor binding
@nl
prefLabel
The crystal structure of vascu ...... exibility and receptor binding
@ast
The crystal structure of vascu ...... exibility and receptor binding
@en
The crystal structure of vascu ...... exibility and receptor binding
@nl
P2093
P3181
P1433
P1476
The crystal structure of vascu ...... exibility and receptor binding
@en
P2093
A M de Vos
H W Christinger
Y A Muller
P304
P3181
P356
10.1016/S0969-2126(97)00284-0
P577
1997-10-15T00:00:00Z