Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523
about
Yersinia enterocolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretionStructural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2′-hydroxydibenz[b,f]azepin-5-yl)methylpteridineCrystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and SelectivityMultiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate ResistanceTheZisomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complexProteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small moleculesTobacco budworm dihydrofolate reductase is a promising target for insecticide discovery.The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.Advances in quantitative structure-activity relationship models of antimalarials.2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition.In pursuit of virtual lead optimization: the role of the receptor structure and ensembles in accurate docking.In pursuit of virtual lead optimization: pruning ensembles of receptor structures for increased efficiency and accuracy during docking.Interactions of 5-deazapteridine derivatives with Mycobacterium tuberculosis and with human dihydrofolate reductases.Binding mode analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted pteridines with Mycobacterium tuberculosis and human dihydrofolate reductases.
P2860
Q24791724-AD63D0F3-67AA-498A-97C8-770C528C2C19Q27651607-45D80575-55B8-46B6-9C9D-31C25B318ADFQ27654731-A2D0FF75-8279-4974-AD48-5F31D885ED32Q27655667-7C04109B-E011-4EEF-A2F8-10D6C893450EQ27656874-FAA19967-B770-4F2F-A653-9AF9CEBC83A0Q27702464-F0E4EFD4-7795-4132-B656-3FBD1D56696DQ30832627-F228C21A-91AB-48A4-87BC-E5816DCC37F5Q36168008-A1C15007-0FEC-41DF-91F1-EFB855B2D88AQ38029140-1047E993-A44D-4A1F-BDF5-BEF6F7951F31Q39807158-288BDD1E-73CF-485D-A978-33999FF13C0FQ40419101-6C42D680-BA45-4560-B521-CBC64A66DA77Q43170586-83CBF836-8FCA-4302-A4C6-7E16145D6AE8Q45022698-32D971DF-08EC-46BC-811C-996B6E386783Q46841766-D3A7F92D-E679-4E71-B9EA-34512E23B1AF
P2860
Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Comparison of two independent ...... tight-binding inhibitor PT523
@ast
Comparison of two independent ...... tight-binding inhibitor PT523
@en
Comparison of two independent ...... tight-binding inhibitor PT523
@nl
type
label
Comparison of two independent ...... tight-binding inhibitor PT523
@ast
Comparison of two independent ...... tight-binding inhibitor PT523
@en
Comparison of two independent ...... tight-binding inhibitor PT523
@nl
prefLabel
Comparison of two independent ...... tight-binding inhibitor PT523
@ast
Comparison of two independent ...... tight-binding inhibitor PT523
@en
Comparison of two independent ...... tight-binding inhibitor PT523
@nl
P2093
P356
P1433
P1476
Comparison of two independent ...... tight-binding inhibitor PT523
@en
P2093
P304
P356
10.1021/BI971711L
P407
P577
1997-11-11T00:00:00Z