Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines
about
Selective gene silencing by viral delivery of short hairpin RNASmall interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.Crystallographic studies of chemically modified nucleic acids: a backward glanceStability and mismatch discrimination of locked nucleic acid-DNA duplexesExploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonanceA conformational transition in the structure of a 2′-thiomethyl-modified DNA visualized at high resolutionEffect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structureSolution structure of RNA duplexes containing alternating CG base pairs: NMR study of r(CGCGCG)2 and 2'-O-Me(CGCGCG)2 under low salt conditionsCrystal structure of 2'-O-Me(CGCGCG)2, an RNA duplex at 1.30 A resolution. Hydration pattern of 2'-O-methylated RNACrystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stabilitysiRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.Backbone-base inclination as a fundamental determinant of nucleic acid self- and cross-pairing.2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase HProbing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA.Additive CHARMM force field for naturally occurring modified ribonucleotides.Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells.Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing.Linear relationship between deformability and thermal stability of 2'-O-modified RNA hetero duplexes.Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability.Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3'-OH monoribonucleotide.The conformational study of two carbocyclic nucleosides: why carbocyclic nucleic acids (CarNAs) form more stable duplexes with RNA than DNA does.Functional analysis of hairpin ribozyme active site architecture.Antisense oligonucleotides: the next frontier for treatment of neurological disorders.The DinG protein from Escherichia coli is a structure-specific helicase.Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
P2860
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P2860
Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines
description
1994 nî lūn-bûn
@nan
1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
name
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@ast
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@en
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@nl
type
label
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@ast
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@en
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@nl
prefLabel
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@ast
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@en
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@nl
P2093
P1476
Stabilizing effects of the RNA ...... ing 2'-O-methylated adenosines
@en
P2093
P356
10.1016/1074-5521(94)90039-6
P577
1994-09-01T00:00:00Z