Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
about
Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase ICellular roles of dna topoisomerases: a molecular perspectiveThe role of poly(ADP-ribose) in the DNA damage signaling networkThe role of lysine 532 in the catalytic mechanism of human topoisomerase IInhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityStructure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases.Rational design of human DNA ligase inhibitors that target cellular DNA replication and repairEffect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics studyRotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxationDifferential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I.Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyA New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human CellsImmunodetection of human topoisomerase I-DNA covalent complexesA nicked duplex decamer DNA with a PEG(6) tetherArm-site binding by lambda -integrase: solution structure and functional characterization of its amino-terminal domain8-Oxoguanine rearranges the active site of human topoisomerase INonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analogStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexThe role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysisAn Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin TelomeresInsights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State MimicRequirements for catalysis in the Cre recombinase active siteA novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerasesCrystal Structure of a Bacterial Topoisomerase IB in Complex with DNA Reveals a Secondary DNA Binding SiteStructures of Minimal Catalytic Fragments of Topoisomerase V Reveals Conformational Changes Relevant for DNA BindingStructure of Yeast Kinetochore Ndc10 DNA-binding Domain Reveals Unexpected Evolutionary Relationship to Tyrosine RecombinasesProtein design by fusion: implications for protein structure prediction and evolutionYeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.The integrase family of recombinase: organization and function of the active siteTopoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanismTopoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sitesCaspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosisAntifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionComparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cellsStructural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complexBinding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interactionReplacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantCFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA
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P2860
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Crystal structures of human to ...... noncovalent complexes with DNA
@ast
Crystal structures of human to ...... noncovalent complexes with DNA
@en
Crystal structures of human to ...... noncovalent complexes with DNA
@nl
type
label
Crystal structures of human to ...... noncovalent complexes with DNA
@ast
Crystal structures of human to ...... noncovalent complexes with DNA
@en
Crystal structures of human to ...... noncovalent complexes with DNA
@nl
prefLabel
Crystal structures of human to ...... noncovalent complexes with DNA
@ast
Crystal structures of human to ...... noncovalent complexes with DNA
@en
Crystal structures of human to ...... noncovalent complexes with DNA
@nl
P2093
P3181
P1433
P1476
Crystal structures of human to ...... noncovalent complexes with DNA
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.279.5356.1504
P407
P577
1998-03-06T00:00:00Z