Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design
about
Three decades of beta-lactamase inhibitorsThe complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamaseStructural basis for imipenem inhibition of class C beta-lactamases.Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitorsStructure of AmpC β-lactamase (AmpCD) from anEscherichia coliclinical isolate with a tripeptide deletion (Gly286-Ser287-Asp288) in the H10 helixStructural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceStructural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitorsDesign, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as β-Lactamase InhibitorsStructure of the extended-spectrum class C β-lactamase ADC-1 fromAcinetobacter baumanniiSubstrate Deconstruction and the Nonadditivity of Enzyme RecognitionIncreasing Chemical Space Coverage by Combining Empirical and Computational Fragment ScreensTargeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid DerivativeGenetic and kinetic characterization of the novel AmpC β-lactamases DHA-6 and DHA-7.Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase.pKa measurements from nuclear magnetic resonance of tyrosine-150 in class C beta-lactamase.Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis.ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocciInhibition of the class C beta-lactamase from Acinetobacter spp.: insights into effective inhibitor design.Practical methods using boronic acid compounds for identification of class C beta-lactamase-producing Klebsiella pneumoniae and Escherichia coliCharacterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate.A fluorescent carbapenem for structure function studies of penicillin-binding proteins, β-lactamases, and β-lactam sensors.Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase.Inhibitor-sensitive AmpC beta-lactamase variant produced by an Escherichia coli clinical isolate resistant to oxyiminocephalosporins and cephamycins.Beta-lactamase inhibitors: evolving compounds for evolving resistance targets.Characterization, crystallization and preliminary X-ray diffraction analysis of an (S)-specific esterase (pfEstA) from Pseudomonas fluorescens KCTC 1767: enantioselectivity for potential industrial applications.Extended-spectrum cephalosporinases: structure, detection and epidemiology.AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins.Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.Mutation in Serratia marcescens AmpC beta-lactamase producing high-level resistance to ceftazidime and cefpirome.Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase.Functional analyses of AmpC beta-lactamase through differential stability.Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.Label-free fiber optic optrode for the detection of class C β-lactamases expressed by drug resistant bacteria.The versatility of boron in biological target engagement.A fluorescein-labeled AmpC β-lactamase allows rapid characterization of β-lactamase inhibitors by real-time fluorescence monitoring of the β-lactamase-inhibitor interactions.An Efficient Implementation of the Nwat-MMGBSA Method to Rescore Docking Results in Medium-Throughput Virtual Screenings.
P2860
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P2860
Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Three-dimensional structure of ...... hesis and for inhibitor design
@ast
Three-dimensional structure of ...... hesis and for inhibitor design
@en
Three-dimensional structure of ...... hesis and for inhibitor design
@nl
type
label
Three-dimensional structure of ...... hesis and for inhibitor design
@ast
Three-dimensional structure of ...... hesis and for inhibitor design
@en
Three-dimensional structure of ...... hesis and for inhibitor design
@nl
prefLabel
Three-dimensional structure of ...... hesis and for inhibitor design
@ast
Three-dimensional structure of ...... hesis and for inhibitor design
@en
Three-dimensional structure of ...... hesis and for inhibitor design
@nl
P2093
P356
P1433
P1476
Three-dimensional structure of ...... hesis and for inhibitor design
@en
P2093
B K Shoichet
G S Weston
L C Blaszczak
S J Remington
P304
P356
10.1021/BI981210F
P407
P577
1998-11-17T00:00:00Z