Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
about
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferaseVery important pharmacogene summary: thiopurine S-methyltransferaseThiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in CaucasiansTherapeutic drug monitoring in inflammatory bowel diseaseUsing germline genomics to individualize pediatric cancer treatmentsPharmacogenomics of chemotherapeutic susceptibility and toxicityDrug methylation in cancer therapy: lessons from the TPMT polymorphismDetection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysisThe clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatmentPeliosis hepatis induced by 6-thioguanine administration.Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel diseasePharmacogenomic discovery using cell-based modelsGene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms?Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomicsModel-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose OptimizationThiopurine methyltransferase regulation in rat kidney: immunoprecipitation studiesAssessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic LeukemiaLiquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patientsMethylation of inorganic and organic selenium by the bacterial thiopurine methyltransferase.Revitalizing personalized medicine: respecting biomolecular complexities beyond gene expression.Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls?Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine modelThiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment responseMonitoring thiopurine metabolites in korean pediatric patients with inflammatory bowel diseaseAzathioprine for atopic dermatitis.Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors.Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French populationEcto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics.Clinically relevant genetic variations in drug metabolizing enzymes.Pharmacogenomics: marshalling the human genome to individualise drug therapyPharmacogenetics and responders to a therapy: theoretical background and practical problems.Methylation pharmacogenetics: thiopurine methyltransferase as a model system.Advances in the diagnosis of adverse drug reactions.Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia.Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatmentMechanistic basis of adverse drug reactions: the perils of inappropriate dose schedules.Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.Pharmacogenetics: Part I.Opportunities for translational epidemiology: the important role of observational studies to advance precision oncology.
P2860
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P2860
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
description
1987 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հունվարին հրատարակված գիտական հոդված
@hy
Peer reviewed research article
@en
artículu científicu espublizáu en 1987
@ast
im Januar 1987 veröffentlichter wissenschaftlicher Artikel
@de
vedecký článok (publikovaný 1987-01)
@sk
vědecký článek publikovaný v roce 1987
@cs
wetenschappelijk artikel (gepubliceerd in 1987-01)
@nl
наукова стаття, опублікована в січні 1987
@uk
научни чланак (објављен 1987-01)
@sr
name
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@ast
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@en
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@nl
type
label
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@ast
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@en
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@nl
prefLabel
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@ast
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@en
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@nl
P2093
P3181
P356
P1476
Thiopurine pharmacogenetics in ...... nine nucleotide concentrations
@en
P2093
J A Van Loon
J S Lilleyman
R M Weinshilboum
P2888
P3181
P356
10.1038/CLPT.1987.4
P407
P577
1987-01-01T00:00:00Z
P5875
P6179
1039749325