Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
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Pediatric medulloblastoma - update on molecular classification driving targeted therapiesItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsTargeting the Hedgehog Pathway in Pediatric MedulloblastomaThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyLost in translation: animal models and clinical trials in cancer treatmentHedgehog signaling pathway and its targets for treatment in basal cell carcinomaCIViC databaseMolecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cellsIn vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.Advanced treatment for basal cell carcinomas.NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations.Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Efficacy of cabazitaxel in mouse models of pediatric brain tumorsRAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic TumorsInhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cellsIdentification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop.Targeting hedgehog signaling in cancer: research and clinical developments.Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.The rationale for targeted therapies in medulloblastoma.New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies.RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma.Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Targeted treatment for sonic hedgehog-dependent medulloblastoma.Medulloblastoma development: tumor biology informs treatment decisionsSHH inhibitors for the treatment of medulloblastoma.The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrenceEvolving molecular era of childhood medulloblastoma: time to revisit therapy.Novel therapeutic approaches in chondrosarcoma.Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.Emerging from their burrow: Hedgehog pathway inhibitors for cancer.Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.Pharmacotherapeutic Targeting of G Protein-Coupled Receptors in Oncology: Examples of Approved Therapies and Emerging Concepts.Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma.Targeting GLI proteins in human cancer by small molecules (WO2014116651 A1): a patent evaluation.
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P2860
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
description
2012 nî lūn-bûn
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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@ast
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@en
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model.
@nl
type
label
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@ast
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@en
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model.
@nl
altLabel
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@en
prefLabel
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@ast
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@en
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model.
@nl
P2093
P2860
P3181
P356
P1476
Hedgehog pathway inhibitor sar ...... a mouse medulloblastoma model
@en
P2093
Andrew Richards
Barbara Pullar
Beryl A Hatton
Brandon J Wainwright
Chris Tunkey
Elisabeth H Villavicencio
James M Olson
Julie Randolph-Habecker
Karen McGovern
Keith Robison
P2860
P304
P3181
P356
10.1073/PNAS.1114718109
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P577
2012-05-01T00:00:00Z