Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.

Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.

Item
http://www.wikidata.org/entity/Q27853208
CIViC databaseMolecular predictive markers in tumors of the gastrointestinal tractMaximising the potential of AKT inhibitors as anti-cancer treatmentsActivating Akt1 mutations alter DNA double strand break repair and radiosensitivity.In-vitro and in-vivo combined effect of ARQ 092, an AKT inhibitor, with ARQ 087, a FGFR inhibitor.Accurate detection of low prevalence AKT1 E17K mutation in tissue or plasma from advanced cancer patients.Safety and tolerability of AZD5363 in Japanese patients with advanced solid tumorsRecurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets.Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors.Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN-deficient prostate cancerPhyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways.Implementation of "Clinical Sequencing" in Cancer Genome Medicine in Japan.TERT promoter hotspot mutations in breast cancer.An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers.AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity.
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Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.

Item
http://www.wikidata.org/entity/Q27853208
description
2015 nî lūn-bûn
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2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2015 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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name
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@ast
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@en
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@nl
type
label
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@ast
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@en
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@nl
prefLabel
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@ast
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@en
Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
@nl
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Tumors with AKT1E17K Mutations ...... n Therapy with AKT Inhibitors.
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10.1158/1535-7163.MCT-15-0230
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