alpha-Synuclein locus triplication causes Parkinson's disease
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α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson diseasePhosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismWeb-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's diseasealpha-Synuclein and neuronal cell deathStructures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein proteinGene therapy in Parkinson's disease: rationale and current statusParkinson's disease: from monogenic forms to genetic susceptibility factorsGenetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseGenetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateThe genetic epidemiology of neurodegenerative disease.Blood alpha-synuclein in agricultural pesticide handlers in central Washington StateLRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressThe homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteinsDequalinium-induced protofibril formation of alpha-synucleinAlpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicitySynaptic vesicle trafficking and Parkinson's diseaseNutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathwayLRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyThe role of oxidative stress in Parkinson's diseaseAlpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recyclingFK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53TMolecular determinants of α-synuclein mutants' oligomerization and membrane interactionsSynphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patientsEvidence that alpha-synuclein does not inhibit phospholipase DMutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesp25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathiesPumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levelsInteractions between fatty acids and alpha-synucleinAneuploid neurons are functionally active and integrated into brain circuitryGenetics of Parkinson diseaseGenome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseNext-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutionsSite-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation ratesCognition, language, and clinical pathological features of non-Alzheimer's dementias: an overviewα-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagyGenome-wide association study reveals genetic risk underlying Parkinson's diseaseSecondary structure and dynamics of micelle bound beta- and gamma-synucleinProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases
P2860
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P2860
alpha-Synuclein locus triplication causes Parkinson's disease
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
alpha-Synuclein locus triplication causes Parkinson's disease
@ast
alpha-Synuclein locus triplication causes Parkinson's disease
@en
alpha-Synuclein locus triplication causes Parkinson's disease
@nl
type
label
alpha-Synuclein locus triplication causes Parkinson's disease
@ast
alpha-Synuclein locus triplication causes Parkinson's disease
@en
alpha-Synuclein locus triplication causes Parkinson's disease
@nl
prefLabel
alpha-Synuclein locus triplication causes Parkinson's disease
@ast
alpha-Synuclein locus triplication causes Parkinson's disease
@en
alpha-Synuclein locus triplication causes Parkinson's disease
@nl
P2093
P50
P3181
P356
P1433
P1476
alpha-Synuclein locus triplication causes Parkinson's disease
@en
P2093
A Singleton
D Maraganore
J Blancato
J Kachergus
M Baptista
P3181
P356
10.1126/SCIENCE.1090278
P407
P577
2003-10-31T00:00:00Z