Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
about
Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudiHomology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparumConcurrence of Plasmodium falciparum dhfr and crt mutations in northern GhanaAntimalarial drug resistance: An overviewFalciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic reviewAntimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR NetworkDrug-resistant malaria in Sudan: A review of evidence and scenarios for the futureApplication of genomics to field investigations of malaria by the international centers of excellence for malaria researchTransition-state inhibitors of purine salvage and other prospective enzyme targets in malariaExploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum MalariaInhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovisMutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparumMolecular basis of human cerebral malaria developmentSubstantial increase in mutations in the genes pfdhfr and pfdhps puts sulphadoxine-pyrimethamine-based intermittent preventive treatment for malaria at risk in Burkina FasoTrends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapyTemporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal KenyaPolymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of IndiaMolecular monitoring of Plasmodium falciparum super-resistance to sulfadoxine-pyrimethamine in TanzaniaGold mining areas in Suriname: reservoirs of malaria resistance?Characterization of drug resistance associated genetic polymorphisms among Plasmodium falciparum field isolates in Ujjain, Madhya Pradesh, IndiaA systematic map of genetic variation in Plasmodium falciparumRapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial useA systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquitoHigh resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malariaFitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparumResistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitnessMolecular analysis of chloroquine and sulfadoxine-pyrimethamine resistance-associated alleles in Plasmodium falciparum isolates from NicaraguaDihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, MalaysiaPrevalence of Plasmodium falciparum Molecular Markers of Antimalarial Drug Resistance in a Residual Malaria Focus Area in Sabah, MalaysiaTargeting purine and pyrimidine metabolism in human apicomplexan parasitesHigh-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaTransformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanilA P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuoleBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase IA family of cation ATPase-like molecules from Plasmodium falciparumIn vitro adaptation of Plasmodium falciparum reveal variations in cultivability.A structural annotation resource for the selection of putative target proteins in the malaria parasite.World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.
P2860
Q24631205-8678A83C-1385-425C-A445-A15DCEF851F2Q24802182-CFE4E664-61DC-4928-9A32-903C3A31CC75Q24814551-CB7DAF7E-9282-4568-AA2C-657F50E862ABQ26753085-33AE2E25-FEA6-4094-8C46-8BB436628FC6Q26786140-57D58FA1-E5AD-4142-9CB5-712C513705B0Q26799713-1F114BD5-9A81-4D67-BA1E-3865F1F20D43Q26860010-086612CD-5C32-43F3-BDDB-1EA8BBEA769EQ27010267-3B9150AD-61A8-4D96-8B23-3C9E8E3BBC1FQ27014881-8C846D38-2287-4EA4-87B9-96216DF68CD0Q27653434-C81871E9-1A2D-483E-B83A-ACE35AE17132Q27673544-E610C200-4559-4D13-8D41-9B026AAA1A7EQ27861947-EA0EDA20-76C9-4623-9525-3885A36BCF7FQ28066043-BA62B5A7-F5B7-4FD9-931C-60C5CE87C5B0Q28125898-26FF8D56-D357-47F9-B670-49C797E25777Q28125907-5AE53264-F5C3-4B9F-A547-98E331E86508Q28125913-B90E6E7E-2B9B-4DB9-9424-D08F40CC2F01Q28125914-B0023431-222D-4C31-8FEE-54A5F175F06BQ28125924-66DD7042-FFFE-421C-8BA8-48D7534B02D2Q28125938-2AF75547-3C32-4F16-A4FB-73D7F8AC912EQ28125941-C893C1DA-D1BD-4056-B55D-E1FA8028BAE9Q28125942-EE2660B0-412B-45B0-95B5-921175CF76BDQ28469012-905175F4-B285-40CC-92F3-4ACF6332BDAAQ28469104-A3883219-7C06-45E0-BEA8-E4AFF4BF8CE2Q28473572-ACA299C2-D8E7-4AC6-8933-DE79046241E0Q28474860-D810134A-52E2-4957-9CAE-24C10EE9AC9FQ28475195-3E887747-4AAE-4755-83DC-2DC11BB2EFD4Q28478215-068BA0A0-A88D-49F9-A260-6249573FDF0CQ28478613-BA680CFC-501E-447F-A817-3A7CD0AA73BDQ28538640-14AAB8F6-F826-4AD7-B336-95E221304C2FQ28550436-86B23DCA-BA51-4810-83DD-11B8FF2D7B3BQ28553013-EF18E3BC-35DE-4466-9DE4-771829D94657Q28629739-D5B7F3FF-8816-4453-AC6B-906CB06C37B6Q28829342-76223A27-FA9A-4EC4-9FED-218BB5CE87C0Q29619882-0A18D063-6294-4411-9956-34EED13FF66AQ30039339-1EB2A13C-F5B4-4C5B-8149-D7F3F693EA1FQ30044485-2D31611A-D55F-4581-8436-6C260D900B26Q30048208-7D9002DF-F82B-4F1D-A03A-0DB562A72988Q30277705-D719352F-254B-4D50-96B1-2A0043710064Q30369560-029C7BFF-CC89-4356-9F16-326564759A41Q30483555-3B611B42-906D-4940-BFCC-0AE5135EE7D5
P2860
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
description
1988 nî lūn-bûn
@nan
1988 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Evidence that a point mutation ...... thamine in falciparum malaria.
@ast
Evidence that a point mutation ...... thamine in falciparum malaria.
@en
Evidence that a point mutation ...... thamine in falciparum malaria.
@nl
type
label
Evidence that a point mutation ...... thamine in falciparum malaria.
@ast
Evidence that a point mutation ...... thamine in falciparum malaria.
@en
Evidence that a point mutation ...... thamine in falciparum malaria.
@nl
prefLabel
Evidence that a point mutation ...... thamine in falciparum malaria.
@ast
Evidence that a point mutation ...... thamine in falciparum malaria.
@en
Evidence that a point mutation ...... thamine in falciparum malaria.
@nl
P2093
P2860
P921
P3181
P356
P1476
Evidence that a point mutation ...... thamine in falciparum malaria.
@en
P2093
D S Peterson
D Walliker
T E Wellems
P2860
P304
P3181
P356
10.1073/PNAS.85.23.9114
P407
P577
1988-12-01T00:00:00Z