Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
about
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathBlm10 binds to pre-activated proteasome core particles with open gate conformation.Inhibition of proteasomal degradation of rpn4 impairs nonhomologous end-joining repair of DNA double-strand breaks.Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation.The C-terminal extension of the beta7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturation.Mapping of yeast Rpn4p transactivation domains.Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase.A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor.The 26S proteasome drives trinucleotide repeat expansionsAnalysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress responseRegulatory mechanisms involved in the control of ubiquitin homeostasisIdentification of the preferential ubiquitination site and ubiquitin-dependent degradation signal of Rpn4Yeast biological networks unfold the interplay of antioxidants, genome and phenotype, and reveal a novel regulator of the oxidative stress responseProteasomal degradation of Rpn4 in Saccharomyces cerevisiae is critical for cell viability under stressed conditions.Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiaeA proteasome for all occasions.A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.Proteasome plasticity.Proteasome-associated proteins: regulation of a proteolytic machine.Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications.Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis.Disruption of Rpn4-induced proteasome expression in Saccharomyces cerevisiae reduces cell viability under stressed conditions.Cdc48 chaperone and adaptor Ubx4 distribute the proteasome in the nucleus for anaphase proteolysis.Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast cancer cells.Yeast Pah1p phosphatidate phosphatase is regulated by proteasome-mediated degradation.Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2.A role for the proteasome in the turnover of Sup35p and in [PSI(+) ] prion propagation.Proteasome stress sensitizes malignant pleural mesothelioma cells to bortezomib-induced apoptosis.Proteasome inhibition enhances resistance to DNA damage via upregulation of Rpn4-dependent DNA repair genes.Identifying functional modules using expression profiles and confidence-scored protein interactions.
P2860
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P2860
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@ast
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@en
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@nl
type
label
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@ast
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@en
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@nl
prefLabel
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@ast
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@en
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@nl
P2093
P2860
P3181
P1433
P1476
Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.
@en
P2093
Birgit I Keck
Markus K London
Paula C Ramos
R Jürgen Dohmen
P2860
P304
P3181
P356
10.1016/J.FEBSLET.2004.04.078
P407
P577
2004-06-04T00:00:00Z