Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability.
about
Glycine-alanine repeats impair proper substrate unfolding by the proteasomeThe expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complexA genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicingThe 26S proteasome drives trinucleotide repeat expansionsA novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base.The assembly pathway of the 19S regulatory particle of the yeast 26S proteasomeDisordered proteinaceous machinesC. elegans dss-1 is functionally conserved and required for oogenesis and larval growth.Designed proteins to modulate cellular networksSchizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.The over-expression of the β2 catalytic subunit of the proteasome decreases homologous recombination and impairs DNA double-strand break repair in human cells.The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway.Assembly, structure, and function of the 26S proteasome.DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.Sem1: a versatile "molecular glue"?Destroying the ring: Freeing DNA from Ku with ubiquitin.Base-CP proteasome can serve as a platform for stepwise lid formationDss1 interaction with Brh2 as a regulatory mechanism for recombinational repairProteasome plasticity.Proteasome-associated proteins: regulation of a proteolytic machine.Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling.GammaH2AX and its role in DNA double-strand break repair.The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome.Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesisSem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.Dss1 regulates interaction of Brh2 with DNA.Functional assays for analysis of variants of uncertain significance in BRCA2.BRCA2: one small step for DNA repair, one giant protein purified.DSSylation, a novel guide for protein degradation?A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing.Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.Evidence that the Arabidopsis Ubiquitin C-terminal Hydrolases 1 and 2 associate with the 26S proteasome and the TREX-2 complexIdentification and characterization of a Drosophila proteasome regulatory network.Dss1 is a 26S proteasome ubiquitin receptor.
P2860
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P2860
Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@ast
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@en
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@nl
type
label
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@ast
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@en
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@nl
prefLabel
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@ast
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@en
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@nl
P2093
P356
P1476
Sem1, the yeast ortholog of a ...... enhances proteasome stability.
@en
P2093
Hideki Kobayashi
Irina Velichutina
Minoru Funakoshi
P304
P356
10.1242/JCS.01575
P407
P577
2004-12-15T00:00:00Z