Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.
about
Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membraneThe Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44.Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathwayResidues of Tim44 involved in both association with the translocon of the inner mitochondrial membrane and regulation of mitochondrial Hsp70 tetheringThe mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.Protein unfolding by mitochondria. The Hsp70 import motorRole of the loop L4,5 in allosteric regulation in mtHsp70s: in vivo significance of domain communication and its implications in protein translocationMitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.Surface accessibility of the 70-kilodalton Chlamydia trachomatis heat shock protein following reduction of outer membrane protein disulfide bonds.On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.The interaction of the chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) with ribosome-bound nascent chains examined using photo-cross-linkingRole of membrane contact sites in protein import into mitochondria.Unfolding of preproteins upon import into mitochondria.Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence.Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondriaThe protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation.The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences.Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins.Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.Substrate-induced assembly of a contiguous channel for protein export from E.coli: reversible bridging of an inner-membrane translocase to an outer membrane exit pore.A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein import.DNA polymerase beta participates in mitochondrial DNA repair.
P2860
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P2860
Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Differential requirement for t ...... translocation of preproteins.
@ast
Differential requirement for t ...... translocation of preproteins.
@en
Differential requirement for t ...... translocation of preproteins.
@nl
type
label
Differential requirement for t ...... translocation of preproteins.
@ast
Differential requirement for t ...... translocation of preproteins.
@en
Differential requirement for t ...... translocation of preproteins.
@nl
prefLabel
Differential requirement for t ...... translocation of preproteins.
@ast
Differential requirement for t ...... translocation of preproteins.
@en
Differential requirement for t ...... translocation of preproteins.
@nl
P2093
P2860
P1433
P1476
Differential requirement for t ...... d translocation of preproteins
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1996.TB00627.X
P407
P577
1996-06-01T00:00:00Z