A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization
about
Transition-state inhibitors of purine salvage and other prospective enzyme targets in malariaThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseWild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS?Targeting purine and pyrimidine metabolism in human apicomplexan parasitesAntimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysisPlasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase.Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.Malaria parasite carbonic anhydrase: inhibition of aromatic/heterocyclic sulfonamides and its therapeutic potential.Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum.Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferasesSynthesis of orotidine by intramolecular nucleosidation.Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase.
P2860
Q27014881-629DF0F0-E538-4B95-A02C-0FA3D4600866Q27667488-FF4451EC-4E5D-4421-8024-B449B792A46FQ27676270-95AD4BBF-AAE6-45C9-A796-D1D2F637819CQ27680432-92CD266D-F6E1-4174-8F44-E446A6BC302CQ28480557-F77E3807-AB91-413A-B373-28C9BCFDBDFAQ28629739-AF46107F-CDDC-4CB0-B6F5-07344FF65123Q33679330-E47C71EC-EC60-4C35-A4AD-8F09C1BE52D8Q33903812-B5ABE3AE-CF78-4DE9-8600-D31F392AB4B1Q34013149-23F78B68-46A7-449C-9681-F2BDC2B71740Q34149050-D5C9411A-0E9D-4BC5-99AA-17C2AD4A2032Q34660349-166F1744-28A4-4B0D-9316-0573541512D8Q36459710-634244C5-C7B3-49C6-A2C9-DBBAF737F34FQ37159817-C55EF919-BEDA-4236-9297-10E8A0D6D531Q39453006-07983997-2A5A-462D-8571-7F8444B118A0Q40917690-9AA16E0B-402B-4F50-86DF-44C466D2A61AQ41459340-3BCDC0FF-6D34-41C4-B574-C25C631945EBQ45948149-AF5F2140-0510-4DEA-BA50-BF66EE9A89DEQ46393178-01134AA2-54DD-4832-914A-DFD60E73E7E3
P2860
A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A novel enzyme complex of orot ...... nd inhibition characterization
@ast
A novel enzyme complex of orot ...... nd inhibition characterization
@en
A novel enzyme complex of orot ...... nd inhibition characterization
@nl
type
label
A novel enzyme complex of orot ...... nd inhibition characterization
@ast
A novel enzyme complex of orot ...... nd inhibition characterization
@en
A novel enzyme complex of orot ...... nd inhibition characterization
@nl
prefLabel
A novel enzyme complex of orot ...... nd inhibition characterization
@ast
A novel enzyme complex of orot ...... nd inhibition characterization
@en
A novel enzyme complex of orot ...... nd inhibition characterization
@nl
P2093
P921
P356
P1433
P1476
A novel enzyme complex of orot ...... nd inhibition characterization
@en
P2093
Brian J DelFraino
Jeffrey A Smiley
Jerapan Krungkrai
Phisit Prapunwattana
Sudaratana R Krungkrai
Toshihide Mitamura
Toshihiro Horii
P304
P356
10.1021/BI048439H
P407
P577
2005-02-08T00:00:00Z