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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

http://www.wikidata.org/entity/Q28025527

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Development and Validation of a Computational Model for Androgen Receptor Activity High-Throughput Screening Data Interpretation in the Context of In Vivo Transcriptomic Responses to Oral Cr(VI) Exposure.Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library.Predicting organ toxicity using in vitro bioactivity data and chemical structure.Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.Linking physiological parameters to perturbations in the human exposome: Environmental exposures modify blood pressure and lung function via inflammatory cytokine pathway.An "EAR" on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure-Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters.(Q)SARs to predict environmental toxicities: current status and future needs.An Integrated Chemical Environment to Support 21st-Century Toxicology.Chemical activity-based environmental risk analysis of the plasticizer di-ethylhexyl phthalate and its main metabolite mono-ethylhexyl phthalate.Zebrafish in Toxicology and Environmental Health.In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects.The CompTox Chemistry Dashboard: a community data resource for environmental chemistry.The Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course.Consumer product chemical weight fractions from ingredient lists.High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis.Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology.Pathway design using de novo steps through uncharted biochemical spaces.Identification of potential aryl hydrocarbon receptor ligands by virtual screening of industrial chemicals.Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.Adverse outcome pathways: a concise introduction for toxicologists.Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.Screening the Toxcast Phase 1 Chemical Library For Inhibition of Deiodinase Type 1 Activity.Automating data analysis for two-dimensional gas chromatography/time-of-flight mass spectrometry non-targeted analysis of comparative samples.Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.The Need for, and the Role of the Toxicological Chemist in the Design of Safer Chemicals.A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.MoleculeNet: a benchmark for molecular machine learning.OPERA models for predicting physicochemical properties and environmental fate endpoints.Advanced tools for the safety assessment of nanomaterials The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products.High-throughput screening of chemicals as functional substitutes using structure-based classification models Uncertainty quantification in ToxCast high throughput screening Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line

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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

http://www.wikidata.org/entity/Q28025527

description

2016 nî lūn-bûn

@nan

2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի օգոստոսին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

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Chemical Research in Toxicology

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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

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Ann M Richard

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Chihae Yang

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Inthirany Thillainadarajah

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James Rathman

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Keith A Houck

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The Chemistry Development Kit (CDK): an open-source Java library for Chemo- and Bioinformatics

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1225-1251

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scholarly article

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10.1021/ACS.CHEMRESTOX.6B00135

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8

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29

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John F. Wambaugh

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27367298

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