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A tetrazolyl-substituted subtype-selective AMPA receptor agonistMolecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterizationThermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamateA new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structureStudies on an ( S )-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural CharacterizationKainate induces various domain closures in AMPA and kainate receptorsPharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptorsChemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transportersStructural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domainSynthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffoldL-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domainMolecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand binding domainPositive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzStudies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
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description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Karla Frydenvang
@ast
Karla Frydenvang
@en
Karla Frydenvang
@es
Karla Frydenvang
@sl
type
label
Karla Frydenvang
@ast
Karla Frydenvang
@en
Karla Frydenvang
@es
Karla Frydenvang
@sl
prefLabel
Karla Frydenvang
@ast
Karla Frydenvang
@en
Karla Frydenvang
@es
Karla Frydenvang
@sl