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Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experimentsStudies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers.Decoding Biosynthetic Pathways in Plants by Pulse-Chase Strategies Using (13)CO₂ as a Universal Tracer †Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoidsThe structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthaseBiosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase ICrystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding foldStructural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug developmentA structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicusCrystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilisBiosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinaseStructure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanismStructure and Properties of an Engineered Transketolase from MaizeThe structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolutionLumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug designSynthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesisA new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implicatCharacterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discoveryStructure of lumazine protein, an optical transponder of luminescent bacteriaInhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysisStructure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reductionProbing the reaction mechanism of IspH protein by x-ray structure analysisStructural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracisBiosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspGInhibitors of the herbicidal target IspD: allosteric site bindingDiscovery of acetylene hydratase activity of the iron–sulphur protein IspHReverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesisStructures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspHCrystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysisAre Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic InvestigationBiosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5Å resolutionInsights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspHStructure and reaction mechanism of pyrrolysine synthase (PylD)IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isostersPseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspDThe formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD)Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspCCharacterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growthBiosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Adelbert Bacher
@ast
Adelbert Bacher
@en
Adelbert Bacher
@es
type
label
Adelbert Bacher
@ast
Adelbert Bacher
@en
Adelbert Bacher
@es
prefLabel
Adelbert Bacher
@ast
Adelbert Bacher
@en
Adelbert Bacher
@es