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Correlation of structure and function in the human hotdog-fold enzyme hTHEM4Crystal structure of human thioesterase superfamily member 2The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1aThe mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysisThe Enzyme Function Initiative.Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolasePyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysisX-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesteraseDissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutantsThe pentacovalent phosphorus intermediate of a phosphoryl transfer reactionThe structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SUX-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysisCharacterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lambliaThe X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical functionRational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate: Coenzyme A Ligase for Expanded Substrate Range † , ‡ , §Swiveling domain mechanism in pyruvate phosphate dikinaseStructure and Function of PA4872 from Pseudomonas aeruginosa , a Novel Class of Oxaloacetate Decarboxylase from the PEP Mutase/Isocitrate Lyase SuperfamilyStructure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesteraseThe catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition stateStructural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase † ‡Structure-Function Analysis of 2-Keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate Phosphatase Defines Specificity Elements in Type C0 Haloalkanoate Dehalogenase Family MembersStructure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily memberAnalysis of the Structural Determinants Underlying Discrimination between Substrate and Solvent in β-Phosphoglucomutase Catalysis † ‡The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligaseX-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasiteGiardia lambliaStructural Determinants of Substrate Recognition in the HAD Superfamily Member d - glycero - d - manno -Heptose-1,7-bisphosphate Phosphatase (GmhB),X-ray structure and characterization of carbamate kinase from the human parasiteGiardia lambliaRational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolaseThe Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. Strain SUDivergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic PyrophosphataseThe X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions inB. thetaiotaomicronStructural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid BiosynthesisStructure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugsStructure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdBStructure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutationHomo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1Analysis of the substrate specificity loop of the HAD superfamily cap domainCrystal structure of the petal death protein from carnation flower.Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis.Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes.
P50
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P50
description
hulumtuese
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onderzoeker
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researcher
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հետազոտող
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name
Debra Dunaway-Mariano
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Debra Dunaway-Mariano
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Debra Dunaway-Mariano
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Debra Dunaway-Mariano
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type
label
Debra Dunaway-Mariano
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Debra Dunaway-Mariano
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Debra Dunaway-Mariano
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Debra Dunaway-Mariano
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prefLabel
Debra Dunaway-Mariano
@ast
Debra Dunaway-Mariano
@en
Debra Dunaway-Mariano
@es
Debra Dunaway-Mariano
@sl