Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
about
Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingAdvances in Autophagy Regulatory MechanismsThe apo-structure of the leucine sensor Sestrin2 is still elusiveRecent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingC9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.Child Stunting is Associated with Low Circulating Essential Amino Acids.Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs.Mechanism of arginine sensing by CASTOR1 upstream of mTORC1The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?Chronic rapamycin treatment on the nutrient utilization and metabolism of juvenile turbot (Psetta maxima).Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.The lysosome as a command-and-control center for cellular metabolism.Unsolved mysteries of Rag GTPase signaling in yeast.Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathwayTGFβ1-induced leucine limitation uncovered by differential ribosome codon reading.mTOR Signaling in Growth, Metabolism, and Disease.Biochemical Basis of Sestrin Physiological Activities.Physiological processes underlying organ injury in alcohol abuse.T-cell metabolism governing activation, proliferation and differentiation; a modular view.Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view.Dietary protein supplementation in the elderly for limiting muscle mass loss.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Nutrient sensing and TOR signaling in yeast and mammals.Cell biology in China: Focusing on the lysosome.Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids.Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells.Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancerStatin and Bisphosphonate Induce Starvation in Fast-Growing Cancer Cell Lines.The Architecture of the Rag GTPase Signaling Network.Rags to riches: Amino acid sensing by the Rag GTPases in health and disease.Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.Branched-chain amino acid metabolism in cancer.
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P2860
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
description
2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2016
@ast
im Januar 2016 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2016/01/01)
@sk
vědecký článek publikovaný v roce 2016
@cs
wetenschappelijk artikel (gepubliceerd op 2016/01/01)
@nl
наукова стаття, опублікована в січні 2016
@uk
name
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@ast
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@en
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@nl
type
label
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@ast
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@en
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@nl
prefLabel
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@ast
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@en
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
@en
P2093
Kevin E Knockenhauer
Lynne Chantranupong
Michael E Pacold
Rachel L Wolfson
Robert A Saxton
P2860
P3181
P356
10.1126/SCIENCE.AAD2087
P407
P577
2016-01-01T00:00:00Z