Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
about
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismMolecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteinsSPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bCharacterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteinsIFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress responseCREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysisThe hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBPDimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin betaA proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodNuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-ZipCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLA family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factorsDual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processingExpression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complexThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinomaThe roles of intramembrane proteases in protozoan parasitesMaking the cut: central roles of intramembrane proteolysis in pathogenic microorganismsStructural basis for intramembrane proteolysis by rhomboid serine proteasesOpen-cap conformation of intramembrane protease GlpGStructure of a site-2 protease family intramembrane metalloproteaseCleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavageThe conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.A century of cholesterol and coronaries: from plaques to genes to statinsTranscriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1The proprotein convertases and their implication in sterol and/or lipid metabolismAn internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain proteinp97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibitionAsparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 proteaseA role for smooth endoplasmic reticulum membrane cholesterol ester in determining the intracellular location and regulation of sterol-regulatory-element-binding protein-2Identification of an archaeal presenilin-like intramembrane proteasePERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationRegulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cellsDecreased lipid synthesis in livers of mice with disrupted Site-1 protease geneMaintaining cholesterol homeostasis: sterol regulatory element-binding proteinsYY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genesCleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studiesDifferential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteinsSelf-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide.
P2860
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P2860
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
description
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
scientific journal article
@en
vedecký článok (publikovaný 1997/12/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/12/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в грудні 1997
@uk
مقالة علمية (نشرت في ديسمبر 1997)
@ar
name
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@ast
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@en
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@nl
type
label
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@ast
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@en
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@nl
prefLabel
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@ast
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@en
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@nl
P2093
P3181
P1433
P1476
Complementation cloning of S2P ...... tramembrane cleavage of SREBPs
@en
P2093
D. Nijhawan
J. L. Goldstein
M. S. Brown
M. T. Hasan
N. G. Zelenski
R. B. Rawson
T. Y. Chang
P3181
P356
10.1016/S1097-2765(00)80006-4
P577
1997-12-01T00:00:00Z