Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion
about
Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorPTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1Spatial regulation of RhoC activity defines protrusion formation in migrating cellsDetection of Brk expression in non-small cell lung cancer: clinicopathological relevance.Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration.Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer.Brk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKRho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyMechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowthBRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRSuppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer.Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast CancersSILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.Abnormal expression of p190RhoGAP in colorectal cancer patients with poor survival.Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.PTK6 promotes hepatocellular carcinoma cell proliferation and invasion.Glucocorticoid receptor DNA binding factor 1 expression and osteosarcoma prognosis.Ras and Rho GTPases on the move: The RasGRF connection.PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.Regulation of Rho GTPase activity at the leading edge of migrating cells by p190RhoGAP.Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus.Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers.Signaling by PTK6
P2860
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P2860
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion
description
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Oktober 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/10/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/10/01)
@nl
наукова стаття, опублікована в жовтні 2008
@uk
مقالة علمية (نشرت في أكتوبر 2008)
@ar
name
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@ast
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@en
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@nl
type
label
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@ast
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@en
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@nl
prefLabel
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@ast
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@en
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@nl
P2093
P921
P3181
P1433
P1476
Breast tumor kinase phosphoryl ...... rowth, migration, and invasion
@en
P2093
Che-Hung Shen
Cheng-Chi Chang
Fang-Yen Li
Hsin-Yi Chen
Jeffrey Settleman
Ming-Shien Lin
Ruey-Hwa Chen
P304
P3181
P356
10.1158/0008-5472.CAN-08-0997
P407
P577
2008-10-01T00:00:00Z