An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
about
Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolaseRegulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gammaMultiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cellsHuman leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidasesTapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathwayAmyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I moleculeSpecificity of amyloid precursor-like protein 2 interactions with MHC class I moleculesIntracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-PresentationAlternative Antigen Processing for MHC Class I: Multiple Roads Lead to RomeEndoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseWhat is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimmingA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingStructural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional SpecializationFrom HLA-B27 to spondyloarthritis: a journey through the ER.Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune DiseasesERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulumThe ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residuesRequirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-EDistribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometriumInvolvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cellsInteraction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.EpiJen: a server for multistep T cell epitope prediction.The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Pathways of antigen processing.ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surfaceCutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeThe host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationEpistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish populationPA28αβ: the enigmatic magic ring of the proteasome?Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.
P2860
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P2860
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
scientific journal article
@en
vedecký článok (publikovaný 2002/12/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@ast
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@en
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@nl
type
label
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@ast
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@en
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@nl
prefLabel
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@ast
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@en
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@nl
P2093
P3181
P356
P1433
P1476
An IFN-gamma-induced aminopept ...... MHC class I-presented peptides
@en
P2093
Akira Hattori
Alfred L. Goldberg
Ian A. York
Kenneth L. Rock
Masafumi Tsujimoto
Shih-Chung Chang
Shirley Markant
Tomo Saric
P304
P3181
P356
10.1038/NI859
P407
P577
2002-12-01T00:00:00Z