Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors
about
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateImplications of CAD and DNase II in ischemic neuronal necrosis specific for the primate hippocampusThe cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityCysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's diseaseThe role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal modelsExpression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicityOxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Focal cerebral ischemia induces active proteases that degrade microvascular matrix.Protective mechanisms by cystatin C in neurodegenerative diseases.The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation.Cystatin C in Alzheimer's disease.Lysosomal membrane permeabilization as a key player in brain ischemic cell death: a "lysosomocentric" hypothesis for ischemic brain damage.HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat NeurotoxicityCystatin C in aging and in Alzheimer's disease.Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone.3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxinPET imaging of ischemic neuronal death in the hippocampus of living monkeys.Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death.Cystatin C is differentially involved in multiple system atrophy phenotypes.
P2860
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P2860
Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@ast
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@en
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@nl
type
label
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@ast
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@en
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@nl
prefLabel
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@ast
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@en
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@nl
P2093
P356
P1476
Postictal blockade of ischemic ...... selective cathepsin inhibitors
@en
P2093
E Kominami
J Yamashita
K Tsuchiya
T Yamashima
T Yoshioka
P304
P356
10.1006/EXNR.1998.6988
P407
P577
1999-02-01T00:00:00Z