Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms
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Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivoryTwo domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcriptionIsoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic DiseaseIncreased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase PiUse of transgenic mice in UDP-glucuronosyltransferase (UGT) studiesDomestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma.UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetablesHumanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide.Pain management in cats--past, present and future. Part 1. The cat is unique.Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term.Coordinate regulation of drug metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters.Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.Cloning of UGT1A9 cDNA from liver tissues and its expression in CHL cells.Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies.Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomesFeline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms.Veterinary Compounding: Regulation, Challenges, and Resources.N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.Bioactivation of herbal constituents: simple alerts in the complex system.ABCG2 transporter: therapeutic and physiologic implications in veterinary species.Osteoarthritis in the cat: 2. how should it be managed and treated?Practical use of opioids in cats: a state-of-the-art, evidence-based review.Clinical and laboratory features of cats with feline infectious peritonitis--a retrospective study of 231 confirmed cases (2000-2010).Uridine Diphosphate-Glucuronosyltransferase (UGT) Xenobiotic Metabolizing Activity and Genetic Evolution in Pinniped Species.Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes.UDP-glucuronosyltransferase (UGT) 2B subfamily interspecies differences in carnivores.Multimodal analgesia for perioperative pain in three cats.Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam.The pharmacokinetics of intravenous fenoldopam in healthy, awake cats.Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats.Feline head and neck squamous cell carcinoma: a natural model for the human disease and development of a mouse model.Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6.Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences.Pharmacokinetics of ibafloxacin in healthy cats.Pharmacokinetics of buprenorphine following intravenous and buccal administration in cats, and effects on thermal threshold.Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats.PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration.Pharmacokinetics of intravenous ketorolac in cats undergoing gonadectomy.Identification of interspecific differences in phase II reactions: determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene.
P2860
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P2860
Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@ast
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@en
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@nl
type
label
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@ast
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@en
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@nl
prefLabel
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@ast
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@en
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@nl
P1476
Molecular genetic basis for de ...... pressed hepatic UGT1A isoforms
@en
P2093
D J Greenblatt
P304
P356
10.1097/00008571-200006000-00009
P407
P577
2000-06-01T00:00:00Z