Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
about
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and functionThe sonic hedgehog-patched-gli pathway in human development and diseaseActivation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activationMediator modulates Gli3-dependent Sonic hedgehog signalingA potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues.Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic developmentDistinct roles of PTCH2 splice variants in Hedgehog signallingGli proteins and the control of spinal-cord patterningA gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tubeFrom nose to brain: development of gonadotrophin-releasing hormone-1 neuronesGLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cellsEstablishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedbackThe magnitude of hedgehog signaling activity defines skin tumor phenotypeDorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activityFrom fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung developmentRoles for Hedgehog signaling in adult organ homeostasis and repairSonic hedgehog signaling in the development of the mouse hypothalamusContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyThe Hedgehog signalling pathway in bone formationMaking a grade: Sonic Hedgehog signalling and the control of neural cell fateAnalysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathwaysSonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationThe transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse developmentForward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signalingActivation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regenerationThe intraflagellar transport protein IFT80 is required for cilia formation and osteogenesisSonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanismGLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cellsA direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cordIncreased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programsGas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehogLimb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterningGli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossificationProgenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activityLoss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalusA mutation in the mouse ttc26 gene leads to impaired hedgehog signalingThe expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarus
P2860
Q21145277-F5123F70-581E-456A-9D0A-5A6D752DC1B0Q24290288-CF4B3782-628B-449D-9BB7-E5367E41331DQ24293190-591CB062-67F0-4D49-A8FE-D8A828B5246BQ24304401-CEEEC08C-9D93-4553-BFE1-DE107C882591Q24309518-48679686-9414-4C00-9C2E-F4A2B65734BDQ24318805-592105F4-CDB6-4674-AD49-10069B49B9F1Q24529871-C1630A13-47E3-4832-B8F4-57285C98D587Q24530681-7360E981-99C2-405F-B7F9-D966EF99D236Q24536036-05102F72-8A10-40D1-A64B-152B12DE0105Q24556567-6219398D-9F0F-4303-B42B-3B73E43E7B97Q24633621-1F286488-F66A-42E4-B888-027AE38E5A64Q24653046-115232D7-C9B9-470E-9F50-082D97E95A13Q24656671-281A6AE0-EF27-4F8B-9C2A-45E92A8A381BQ24671053-3F2DE4AB-41E4-4547-855A-EE66701B82A2Q24682634-766F6E11-1C8F-4117-8285-0D88336BF06DQ24791126-FAEFDA2A-E772-4AD3-8841-37F52E39A2CBQ26823066-442B469F-EC81-4FE2-8D6F-710919A1C289Q26866111-4663BF51-5153-4251-8AFF-C60BBA3BB69FQ27027214-E502E24F-97C2-4720-BE37-4CC3119098FEQ28081609-817A4F98-5675-40CA-BF9D-A330B2CBEB54Q28308207-F1F1E239-D5B9-422C-9B34-3B6AA4CA82C6Q28474285-4D88FBEE-BA43-4D7A-A161-AEF97079EA51Q28507411-CF3AF0A9-28A8-4BB6-8484-39AEF9618D64Q28508022-FAB29098-DADE-4BF7-800E-512B9D927301Q28509768-2A42BCDF-233B-4795-A9DE-AAE6C6147263Q28510279-67C2BB4E-0238-4FFF-B8E9-E9F60196FB30Q28512564-352491E7-BD02-4754-8018-54D09C14B64DQ28513239-6733274B-D85F-4C51-A538-88837B4DE997Q28513419-EF91326B-D0D8-4883-A442-0AFFCD69C5EDQ28513713-13966985-97E5-49EE-A91C-0B2B58EF43A8Q28586729-CA81D735-2DD4-4970-94DE-E5082174ED26Q28588215-9D7BBA6B-AF89-424B-9AEE-494B0F24CA0FQ28588813-3855EA3B-F15A-4E77-AEAE-B6AA548E1F8FQ28590845-629D3A64-E10A-47F4-8083-8298B7B4AB65Q28590978-9BAB7CB3-0792-4E98-B939-83B05988B59EQ28591410-6FA78AAC-5315-4844-9920-5F4E2B48A42FQ28592781-166CE0CD-6D34-4058-9A20-D2645E768C37Q28593489-5F81B9C8-8485-402A-9B3B-74FDA6957F22Q28594488-098D548C-AFCD-4297-8896-A6D5B06F587BQ28854334-8ED4A38D-A539-4C36-BFC4-07FAF7362407
P2860
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@ast
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@en
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@nl
type
label
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@ast
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@en
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@nl
prefLabel
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@ast
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@en
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@nl
P2093
P3181
P1433
P1476
Mouse Gli1 mutants are viable ...... mbination with a Gli2 mutation
@en
P2093
A L Joyner
M Nakashima
M P Matise
P304
P3181
P407
P577
2000-04-01T00:00:00Z