Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerShugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cellsDissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.The function of APC/CCdh1 in cell cycle and beyondCharacterization of vertebrate cohesin complexes and their regulation in prophaseInhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1Processing, localization, and requirement of human separase for normal anaphase progressionGermline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibilityThe acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent mannerShugoshin is a Mad1/Cdc20-like interactor of Mad2Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion.Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.Linking sister chromatid cohesion and apoptosis: role of Rad21.Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesisThe emerging role of pituitary tumor transforming gene in tumorigenesisNonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisHuman Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosisEvaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitorsCornelia de Lange syndrome, cohesin, and beyondCell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinaseFrequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumorsMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsAcromegaly pathogenesis and treatmentSeparase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent mannerA novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis.Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexesPTTG/securin activates expression of p53 and modulates its functionEctopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cellsMG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytesSecurin is not required for chromosomal stability in human cellsGlobal approaches to understanding ubiquitination.Sister chromatid segregation in meiosis II: deprotection through phosphorylationQuantitative assessment of chromosome instability induced through chemical disruption of mitotic progressionSpg5 protein regulates the proteasome in quiescence.Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes.
P2860
Q21129300-96594697-0FB5-4353-957E-4E9A4BF59982Q21146367-B4E0238B-199E-458B-BE1B-D9154E724A19Q21146371-DF9A4F53-2C3C-4199-A43A-75A7FCCC1A13Q21203555-D632EEF4-BB09-4B68-860B-4F0BC89EB7A7Q24290512-9C1E9DA1-4DB1-46D6-9DD5-C10D1A52177BQ24291451-F34BCF63-9606-43FB-8910-E506A96A7A5CQ24299175-D420362A-C7CD-4354-985E-32E52BFEEEE4Q24304444-713339BD-45E3-4E2E-B673-151E39295026Q24305568-946A0152-B593-4834-B513-EA2F266A8AE5Q24306351-8B440923-5A87-42E5-AE44-A45F90E690A6Q24307983-543FC246-9473-4D4E-8DB1-52B24791DE79Q24321983-7627B695-6AB5-4172-854F-C67B1B971483Q24534301-4E8ACCDA-3C54-4422-85D5-605ABE96A8B5Q24534348-7FDA3894-4EAB-4987-933E-8ABF1280385BQ24537892-62BC85A9-B822-457D-88B0-5153D19C029AQ24545581-1EAE7AFC-CEC1-419F-970A-382564E21D99Q24548764-E48FE9B2-2D96-48FF-80E9-59C9FB35AA36Q24551182-92B5B23A-EBE3-4793-8FDA-AB21A735BC82Q24558607-6781A91E-1477-4E33-8B35-0B09B5EC9613Q24595585-8E910DF2-83BD-45DA-92FB-CA477663FF84Q24596109-1B5F3A21-E039-4BDF-9A21-3C8D88298580Q24600785-1052EC03-570E-4AE7-AC47-DFEB4815DA3DQ24608202-DBCA2912-DF84-4C86-935C-986861732DFDQ24612772-77DF4615-E9DF-4940-83D3-BBBBC52231FFQ24626904-98886CFF-97CE-427C-BC6E-C678BDC09B14Q24635263-5798D892-2116-4549-882F-C47B09634121Q24647360-152145F2-D973-4508-88DF-152DD9D6B665Q24655049-8ED3A068-6CA4-4A43-829E-62AEE83B3A9FQ24674698-4192152B-2FC4-4AE1-9799-69982099E5D9Q24683190-7A2C894B-AC03-4835-9AAB-4ECEC7F38D2CQ24685911-3395B238-D63A-43E3-959A-CD5B5E04EBB4Q24792982-872F37BB-CFE8-46E1-9982-575545210591Q24798304-007ADDBF-58DC-473C-B23D-499C367F7033Q24798812-CCE4DE9C-C3A2-4A73-A4A9-427B88A5C6EEQ24811013-8BC39530-FDB0-4757-8D32-B896FAB60D58Q24812618-E62FC0FD-513E-4D29-9F13-2EE4AE1C6EDBQ27008999-B57E5869-27B8-43EB-8815-9F270F18766CQ27311350-EF65AC58-821F-4AB6-9D24-717C1B7EE3A3Q27930881-DCAE47C2-DFF6-4C87-9D6C-E260B1BE58E0Q27931850-E30921EF-CCFB-4570-BF11-246F2C9A6123
P2860
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of a vertebrate ...... ansformation and tumorigenesis
@ast
Identification of a vertebrate ...... ansformation and tumorigenesis
@en
Identification of a vertebrate ...... ansformation and tumorigenesis
@nl
type
label
Identification of a vertebrate ...... ansformation and tumorigenesis
@ast
Identification of a vertebrate ...... ansformation and tumorigenesis
@en
Identification of a vertebrate ...... ansformation and tumorigenesis
@nl
prefLabel
Identification of a vertebrate ...... ansformation and tumorigenesis
@ast
Identification of a vertebrate ...... ansformation and tumorigenesis
@en
Identification of a vertebrate ...... ansformation and tumorigenesis
@nl
P2093
P3181
P1433
P1476
Identification of a vertebrate ...... ansformation and tumorigenesis
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.285.5426.418
P407
P577
1999-07-16T00:00:00Z