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Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator.Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibitionShepherding AKT and androgen receptor by Ack1 tyrosine kinaseConformational coupling across the plasma membrane in activation of the EGF receptorAutoinhibition of the insulin-like growth factor I receptor by the juxtamembrane regionT cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationTyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formationRegulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin AThe extracellular architecture of adherens junctions revealed by crystal structures of type I cadherinsNitric oxide and peroxynitrite in health and diseaseTwo adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinaseHuman members of the eukaryotic protein kinase familyResistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implicationsVenus kinase receptors: prospects in signaling and biological functions of these invertebrate kinasesIntersecting roles of protein tyrosine kinase and calcium signaling during fertilizationInvestigation of stable and transient protein-protein interactions: Past, present, and futureTargeting receptor tyrosine kinases in gastric cancerRole of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesisCrystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanismCrystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificityStructure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitorCrystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosisLigand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase familyCrystal structure of a novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathwayA Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine KinasesDesign, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitorsEvidence for chemoreceptors with bimodular ligand-binding regions harboring two signal-binding sitesCracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsMonovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agentStructural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 MutationReceptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancersManipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activityRole of receptor tyrosine kinases in gastric cancer: new targets for a selective therapyThe phospholipase C isozymes and their regulationLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsGenomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosisEffects of macromolecular crowding on protein conformational changesPTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականին հրատարակուած գիտական յօդուած
@hyw
2000 թվականին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Protein tyrosine kinase structure and function
@ast
Protein tyrosine kinase structure and function
@en
Protein tyrosine kinase structure and function
@nl
type
label
Protein tyrosine kinase structure and function
@ast
Protein tyrosine kinase structure and function
@en
Protein tyrosine kinase structure and function
@nl
prefLabel
Protein tyrosine kinase structure and function
@ast
Protein tyrosine kinase structure and function
@en
Protein tyrosine kinase structure and function
@nl
P3181
P1476
Protein tyrosine kinase structure and function
@en
P2093
P304
P3181
P356
10.1146/ANNUREV.BIOCHEM.69.1.373
P407
P577
2000-01-01T00:00:00Z