Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
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The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of SrcMutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2WNT5A mutations in patients with autosomal dominant Robinow syndromeLoss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinasesRor2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinomaThe orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanomaRobinow syndromeROR1, an embryonic protein with an emerging role in cancer biologyThe role of Ryk and Ror receptor tyrosine kinases in Wnt signal transductionmicroRNA regulation of Wnt signaling pathways in development and diseaseRor2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate developmentThe receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathwayThe receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distributionRor2 receptor requires tyrosine kinase activity to mediate Wnt5A signalingRor2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndromeStat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.Wnts' fashion statement: from body stature to dysplasia.Genetic disorders of the skeleton: a developmental approachDistinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B.ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth.Molecular-pathogenetic classification of genetic disorders of the skeleton.The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration.Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive systemExpression of Ror2 mediates invasive phenotypes in renal cell carcinomaRor receptor tyrosine kinases: orphans no more.Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans.9q22 Deletion--first familial case.The genetic basis for skeletal diseases.Identification of duplication downstream of BMP2 in a Chinese family with brachydactyly type A2 (BDA2).Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancerLoss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndromeDVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome.Planar cell polarity signaling in craniofacial development.Answering a century old riddle: brachydactyly type A1.A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.Update on Wnt signaling in bone cell biology and bone disease.Congenital brachydactyly and nail hypoplasia: clue to bone-dependent nail formation.Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.Brachy-syndactyly caused by loss of Sfrp2 functionCritical signal transduction pathways in CLL.
P2860
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P2860
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
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2000 nî lūn-bûn
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2000年の論文
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2000年論文
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Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@ast
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@en
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@nl
type
label
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@ast
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@en
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@nl
prefLabel
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@ast
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@en
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@nl
P2093
P2860
P356
P1433
P1476
Dominant mutations in ROR2, en ...... se, cause brachydactyly type B
@en
P2093
A M Fortuna
A O Wilkie
D M Valenzuela
G D Yancopoulos
M Oldridge
P Propping
R B Kimble
P2860
P2888
P356
10.1038/73495
P407
P577
2000-03-01T00:00:00Z
P6179
1015891122