DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses - Wikidata - wikimedia - TriplyDB

DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses

DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses

http://www.wikidata.org/entity/Q28182624

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Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1 Cytidine deamination induced HIV-1 drug resistance Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all Protein tolerance to random amino acid change Retroviral restriction by APOBEC proteins Multi-scale modeling of HIV infection in vitro and APOBEC3G-based anti-retroviral therapy Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics.Multiple fates of L1 retrotransposition intermediates in cultured human cells.APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon.Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect.Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA.Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination.APOBEC3G targets specific virus species.An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA.Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates.DNA deamination in immunity.Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation.Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 Family.Suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4(+) T cells is associated with inhibition of processive reverse transcription as well as excessive cytidine deamination.Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses.Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif.Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA APOBEC proteins and intrinsic resistance to HIV-1 infection Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.Suppression of human T-cell leukemia virus I gene expression by pokeweed antiviral protein.APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.New insights into the pathogenesis of IgA nephropathy: do toll like receptor 9-B cell activation factor-IgA class switching recombination signaling axis induce IgA hyper-production?Nucleic acid recognition orchestrates the anti-viral response to retroviruses.Antiviral potency of APOBEC proteins does not correlate with cytidine deamination.Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase.Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide.B-cell agonists up-regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function.

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DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses

http://www.wikidata.org/entity/Q28182624

description

2003 nî lūn-bûn

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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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DNA deamination: not just a tr ...... r defense against retroviruses

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DNA deamination: not just a tr ...... r defense against retroviruses

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DNA deamination: not just a tr ...... r defense against retroviruses

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DNA deamination: not just a tr ...... r defense against retroviruses

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DNA deamination: not just a tr ...... r defense against retroviruses

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DNA deamination: not just a tr ...... r defense against retroviruses

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Nature Immunology

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DNA deamination: not just a tr ...... r defense against retroviruses

@en

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Ann M Sheehy

http://www.w3.org/2001/XMLSchema#string

Heather M Craig

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Michael H Malim

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Michael S Neuberger

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P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

DNA deamination mediates innate immunity to retroviral infection

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

Hypermutation of HIV-1 DNA in the absence of the Vif protein

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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641-3

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scholarly article

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10.1038/NI0703-641

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7

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4

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Reuben S Harris

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2003-07-01T00:00:00Z

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10687996

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12830140

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